M2 macrophage microvesicle-inspired nanovehicles improve accessibility to cancer cells and cancer stem cells in tumors

Journal of Nanobiotechnology

Siling Wang¹  Yuqi Wang²  Yaping Li³  Hong Wang³  Xiang Gong³  Yao Wu³  Jie Li³  Xiaoxuan Xu³  Jiaoying Wang³  Zhiwen Zhang⁴ 

[1] School of Pharmacy, Shenyang Pharmaceutical University, 110016, Shenyang, Liaoning, China;School of Pharmacy, Shenyang Pharmaceutical University, 110016, Shenyang, Liaoning, China;State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 201203, Shanghai, China;State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 201203, Shanghai, China;State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 201203, Shanghai, China;Yantai Key Laboratory of Nanomedicine & Advanced Preparations, Yantai Institute of Materia Medica, 264000, Shandong, China;

关键词: Cancer stem cells;    Macrophage;    Microvesicle;    Nanoparticles;    Cabazitaxel;   

DOI  :  10.1186/s12951-021-01143-5

来源: Springer

【 摘 要 】

Cancer cells and cancer stem cells (CSCs) are the major players of cancer malignancy and metastasis, but they are extremely difficult to access. Inspired by the vital role of macrophages and microvesicle-mediated cell–cell communication in tumors, we herein designed M2 macrophage microvesicle-inspired nanovehicle of cabazitaxel (M-CFN) to promote accessibility to cancer cells and CSCs in tumors. In the 4T1 tumor model, M-CFN flexibly permeated the tumor mass, accessed cancer cells and CD90-positive cells, and significantly promoted their entry into CSC fractions in tumors. Moreover, M-CFN treatment profoundly eliminated aldehyde dehydrogenase (ALDH)-expressing CSCs in 4T1 and MCF-7 tumors, produced notable depression of tumor growth and caused 93.86% suppression of lung metastasis in 4T1 models. Therefore, the M2 macrophage microvesicle-inspired nanovehicle provides an encouraging strategy to penetrate the tumor tissues and access these insult cells in tumors for effective cancer therapy.Graphical Abstract

【 授权许可】

CC BY