The role of ferroptosis in lung cancer

Biomarker Research

Q. Ping Dou¹  Daolin Tang²  Jianfei Shen³  Chengchu Zhu³  Sikai Wu³  Xin Chen⁴ 

[1] Department of Oncology, School of Medicine, Barbara Ann Karmanos Cancer Institute, Wayne State University, 48201, Detroit, MI, USA;Departments of Pharmacology & Pathology, School of Medicine, Wayne State University, 48201, Detroit, MI, USA;Department of Surgery, UT Southwestern Medical Center, Dallas, TX, USA;Department of Thoracic Surgery, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Linhai, China;Key Laboratory of Minimally Invasive Techniques & Rapid Rehabilitation of Digestive System Tumor of Zhejiang Province, Linhai, China;Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, School of Basic Medical Sciences, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou, China;

关键词: Ferroptosis;    Lung cancer;    iron;    Lipid peroxidation;    ROS;   

DOI  :  10.1186/s40364-021-00338-0

来源: Springer

【 摘 要 】

Lung cancer is one of the most common cancers in the world. Although medical treatment has made impressive progress in recent years, it is still one of the leading causes of cancer-related deaths in men and women. Ferroptosis is a type of non-apoptotic cell death modality, usually characterized by iron-dependent lipid peroxidation, rather than caspase-induced protein cleavage. Excessive or lack of ferroptosis is associated with a variety of diseases, including cancer and ischaemia-reperfusion injury. Recent preclinical evidence suggests that targeting ferroptotic pathway is a potential strategy for the treatment of lung cancer. In this review, we summarize the core mechanism and regulatory network of ferroptosis in lung cancer cells, and highlight ferroptosis induction-related tumor therapies. The reviewed information may provide new insights for targeted lung cancer therapy.

【 授权许可】

CC BY