Effects of resistance training in healthy older people with sarcopenia: a systematic review and meta-analysis of randomized controlled trials

European Review of Aging and Physical Activity

Barbara E. Ainsworth¹  Xiangfeng He²  Yuwei Feng³  Yu Liu⁴  Nan Chen⁵ 

[1] College of Health Solutions, Arizona State University, Phoenix, AZ, USA;Department of Rehabilitation, Xinhua Hospital Chongming Branch, Shanghai Jiao Tong University, Shanghai, China;Department of Rehabilitation, Xinhua Hospital, Shanghai Jiao Tong University, Shanghai, China;Key Laboratory of Exercise and Health Sciences of Ministry of Education, Shanghai University of Sport, Shanghai, China;Key Laboratory of Exercise and Health Sciences of Ministry of Education, Shanghai University of Sport, Shanghai, China;Department of Rehabilitation, Xinhua Hospital Chongming Branch, Shanghai Jiao Tong University, Shanghai, China;Department of Rehabilitation, Xinhua Hospital, Shanghai Jiao Tong University, Shanghai, China;

关键词: Sarcopenia;    Resistance training;    Body composition;    Muscle strength;    Muscle performance;   

DOI  :  10.1186/s11556-021-00277-7

来源: Springer

【 摘 要 】

ObjectiveWe conducted a meta-analysis to analyze the effects of resistance training on measures of body composition, muscle strength, and muscle performance in older people with sarcopenia.MethodsAll randomized controlled trials on the effects of resistance training on outcome variables in older people with sarcopenia were searched on Pubmed, Embase, Cochrane Library, the China National Knowledge Infrastructure (CNKI), and Wanfang. Data from January 2010 to October 2020 were reviewed. Two researchers extracted data and evaluated the quality of the studies that met the inclusion criteria independently. Meta-analysis for pre-post changes were calculated as standardized mean difference (SMD) with 95% confidence intervals (CI).ResultsFourteen studies meeting inclusion criteria included 561 healthy older adults (age 65.8 to 82.8) with sarcopenia. Compared with the control group, resistance training had positive effects on body fat mass (SMD = -0.53, 95% CI − 0.81 to − 0.25, p = 0.0002, I2 = 0%), handgrip strength (SMD = 0.81, 95%CI 0.35 to 1.27, p = 0.0005, I2 = 81%), knee extension strength (SMD = 1.26, 95% CI 0.72 to 1.80, p < 0.0001, I2 = 67%), gait speed (SMD = 1.28, 95%CI 0.36 to 2.19, p = 0.006, I2 = 89%), and the timed up and go test (SMD = -0.93, 95% CI − 1.30 to − 0.56, p < 0.0001, I2 = 23%). Resistance training had no effects on appendicular skeletal muscle mass (SMD = 0.25, 95% CI − 0.27 to 0.78, p = 0.35, I2 = 68%), skeletal muscle mass (SMD = 0.27, 95% CI − 0.02 to 0.56, p = 0.07, I2 = 0%) and leg lean mass (SMD = 0.12, 95% CI − 0.25 to 0.50, p = 0.52, I2 = 0%). Old people with sarcopenia of different ages, genders or diagnostic criteria and weights have different gains in muscle mass, handgrip strength, knee extension strength and muscle performance after different intervention duration, frequencies, mode and intensity resistance training.ConclusionResistance training is an effective treatment to improve body fat mass, muscle strength, and muscle performance in healthy older people with sarcopenia.

【 授权许可】

CC BY