The Effect of Resistance Training on Muscle and Bone Quality in C57BL/6N mice: Related to Fibroblast Growth Factor Signaling

Resistance training;FGFR signaling;796

SUHAN CHO사범대학 체육교육과 ;

University:서울대학교 대학원

关键词: Resistance training;    FGFR signaling;    796;   

Others  :  http://s-space.snu.ac.kr/bitstream/10371/127440/1/000000141903.pdf

美国|英语

来源: Seoul National University Open Repository

【 摘 要 】

Many studies identified that muscle and bone are functionally interlinked to one another and maintain the quality and strength of muscle and bone are important for quality of human life. Here, I examine the relationship linking Fibroblast growth factors, potential candidates for the role player in muscle and bone cross talk, to bone and muscle quality during growth and resistance exercise. To elucidate the relationship and potential role of FGFs and its signaling, FGFR inhibitor was used while 8 weeks of resistance training was conducted.Administration of FGFR inhibitor decreased grip strength, reduced muscular endurance and running capacity. 8 weeks of inhibitor treatment did not affect muscle mass, body weight or body composition. Inhibitor treatment showed no difference with resistance trained group while the group without inhibitor treatment with exercise showed significant increase in grip strength, muscular and aerobic endurance capacity and maximal load lifted during session. RT-Sham group solely showed hind limb muscle mass increments. FGF2 gene expression responded to resistance training in gastrocnemius muscle but, did not respond much in tibia. However, FGF2 gene expression in tibia exhibited the change in much larger scale than gastrocnemius muscle when inhibitor were treated. Myostatin gene expression in bone and muscle responded opposite to each other with 8 weeks of resistance training.FGFR inhibitor treatment in normal and exercise condition both attenuated muscular strength, endurance and aerobic endurance capacity. 8 weeks of resistance training could not restore the detrimental effects, however seemed to affect FGF-2 mRNA expression in bone. Myostatin responded to resistance training and inhibitors in gastrocnemius muscle but one responded to resistance training in bone tissue. Further analysis is needed to elaborate the definite correlation between gene expressions and resistance training with or without inhibitor treatment.