Potential role of epicardial adipose tissue as a biomarker of anthracycline cardiotoxicity

Insights into Imaging

Caterina Beatrice Monti¹  Maria Del Mar Galimberti Ortiz¹  Moreno Zanardo¹  Davide Capra¹  Francesco Secchi²  Francesco Sardanelli²  Alberto Gianluigi Luporini³  Elena De Benedictis⁴  Pietro Spagnolo⁵  Simone Schiaffino⁵ 

[1]Department of Biomedical Sciences for Health, Università Degli Studi Di Milano, Via Mangiagalli 31, 20133, Milano, Italy

[2]Department of Biomedical Sciences for Health, Università Degli Studi Di Milano, Via Mangiagalli 31, 20133, Milano, Italy

[3]Unit of Radiology, IRCCS Policlinico San Donato, Via Morandi 30, 20097, San Donato Milanese, Italy

[4]Unit of Medical Oncology, IRCCS Policlinico San Donato, Via Morandi 30, 20097, San Donato Milanese, Italy

[5]Unit of Medical Oncology, Policlinico Di Monza, Via Amati 111, 20900, Monza, Italy

[6]Unit of Radiology, IRCCS Policlinico San Donato, Via Morandi 30, 20097, San Donato Milanese, Italy

关键词: Anthracyclines;    Cardiotoxicity;    Breast neoplasms;    Biomarkers;    Tomography, X-ray computed;   

DOI  :  10.1186/s13244-021-01069-4

来源: Springer

【 摘 要 】

BackgroundWe investigated the radiodensity of epicardial (EAT), subcutaneous (SAT), and visceral adipose tissue (VAT) before and after treatment with anthracyclines in a population of breast cancer (BC) patients, and in controls not treated with anthracyclines, to detect a potential role of EAT density as a biomarker of changes related to chemotherapy cardiotoxicity.MethodsWe reviewed BC patients treated with anthracyclines who underwent CT before (CT-t0) and after (CT-t1) chemotherapy, and age- and sex-matched controls who underwent two CT examinations at comparable intervals. On non-contrast scans, EAT was segmented contouring the pericardium and thresholding between -190 and -30 Hounsfield units (HU), and SAT and VAT were segmented with two 15-mm diameter regions of interestthresholded between -195 and -45 HU.ResultsThirty-two female patients and 32 controls were included. There were no differences in age (p = 0.439) and follow-up duration (p = 0.162) between patients and controls. Between CT-t0 and CT-t1, EAT density decreased in BC patients (-66 HU, interquartile range [IQR] -71 to -63 HU, to -71 HU, IQR -75 to -66 HU, p = 0.003), while it did not vary in controls (p = 0.955). SAT density increased from CT-t0 to CT-t1 in BC patients (-107 HU, IQR -111 to -105 HU, to -105 HU, IQR -110 to -100 HU, p = 0.014), whereas it did not change in controls (p = 0.477). VAT density did not vary in either BC patients (p = 0.911) or controls (p = 0.627).ConclusionsEAT density appears to be influenced by anthracycline treatment for BC, well known for its cardiotoxicity, shifting towards lower values indicative of a less active metabolism.

【 授权许可】

CC BY