The association between neutrophil–lymphocyte ratio and poor outcomes following infant cardiac surgery

BMC Cardiovascular Disorders

Peiyao Zhang¹  Liting Bai¹  Peng Gao¹  Xu Wang¹  Yu Jin¹  Jinping Liu¹  Yixuan Li¹ 

[1] Pediatric Cardiac Surgery Center, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of MedicalSciences and Peking Union Medical College, No. 167, North Lishi Road, 100037, Xicheng District, China;

关键词: Pediatric cardiac surgery;    Infants;    Neutrophil–lymphocyte ratio;    Inflammatory response;    Poor outcomes;   

DOI  :  10.1186/s12872-021-02345-3

来源: Springer

【 摘 要 】

BackgroundNeutrophil–lymphocyte ratio (NLR) is a valuable indicator for evaluating inflammation and adverse outcomes after cardiac surgery. The objective of this study was to evaluate the association of perioperative NLR with clinical outcomes in infants undergoing congenital heart surgery with cardiopulmonary bypass.MethodsWe performed a retrospective review of 424 consecutive infants (≤ 1 year) undergoing cardiac surgery between January 2019 and September 2019. Neonates (≤ 28 days) and patients with incomplete NLR data were excluded. The study endpoint was a composite of poor outcomes after surgery. We assess the correlation between perioperative NLR and clinical outcomes. A receiver operating characteristic curve and multivariable logistic regression were applied to identify the prognosis performance of postoperative NLR for poor outcomes.ResultsA total of 68 (16%) infants experienced at least one of the poor outcomes. Postoperative NLR on the third day after the surgery showed the best prognostic significance (AUC = 0.763, 95%CI 0.700–0.826) among perioperative period, with a cut-off value of 2.05. Postoperative NLR was also strongly correlated with mechanical ventilation time, length of ICU and hospital stay (p < 0.001). Multivariable logistic regression revealed that elevated postoperative NLR (OR 3.722, 95%CI 1.895–7.309, p < 0.001) was an independent risk factor for poor outcomes in infants after cardiac surgery.ConclusionsPostoperative NLR was correlated with increased mechanical ventilation time, length of ICU and hospital stay. Elevated postoperative NLR was an independent predictor for poor outcomes after cardiac surgery in infants.

【 授权许可】

CC BY