Long-term corticosteroid-induced chronic glaucoma model produced by intracameral injection of dexamethasone-loaded PLGA microspheres

Drug Delivery

J Ruberte¹  D Garcia-Herranz²  A Aragón-Navas²  J García-Feijoo³  M Subias⁴  T Martinez-Rincón⁴  MJ Rodrigo⁵  S Mendez-Martínez⁶  E Garcia-Martin⁷  L Pablo⁷  MJ Cardiel⁸  I Bravo-Osuna⁹  R Herrero-Vanrell⁹ 

[1] Animal Biotechnology and Gene Therapy Centre (CBATEG), Universitat Autònoma de Barcelona, Bellaterra, Spai;Networked Biomedical Research Centre for Diabetes and Associated Metabolic Diseases (CIBERDEM), Madrid, Spai;Department of Animal Health and Anatomy, School of Veterinary Medicine, Universitat Autònoma de Barcelona, Bellaterra, Spai;Complutense University of Madrid. Innovation, Therapy and Pharmaceutical Development in Ophthalmology (InnOftal) Research Group, UCM 920415, Department of Pharmaceutics and Food Technology, Faculty of Pharmacy, Complutense University of Madrid, Spai;Health Research Institute, San Carlos Clinical Hospital (IdISSC), Madrid, Spai;Complutense University of Madrid. Innovation, Therapy and Pharmaceutical Development in Ophthalmology (InnOftal) Research Group, UCM 920415. National Ocular Pathology Network (OFTARED), Carlos III Health Institute, Spai;Servicio de Oftalmología, Hospital Clínico San Carlos, Madrid, Spai;Departamento de Inmunología, Oftalmología y ORL, Facultad de Medicina, Universidad Complutense de Madrid (UCM), IdISSC, Madrid, Spai;Department of Ophthalmology, Miguel Servet University Hospital, Zaragoza, Spai;Miguel Servet Ophthalmology Research Group (GIMSO), Aragon Health Research Institute (IIS Aragon), Zaragoza, Spai;Department of Ophthalmology, Miguel Servet University Hospital, Zaragoza, Spai;Miguel Servet Ophthalmology Research Group (GIMSO), Aragon Health Research Institute (IIS Aragon), Zaragoza, Spai;National Ocular Pathology Network (OFTARED), Carlos III Health Institute, Madrid, Spai;Department of Ophthalmology, Miguel Servet University Hospital, Zaragoza, Spai;Miguel Servet Ophthalmology Research Group (GIMSO), University of Zaragoza, Aragon Health Research Institute (IIS Aragon), Zaragoza, Spai;Department of Ophthalmology, Miguel Servet University Hospital, Zaragoza, Spai;National Ocular Pathology Network (OFTARED), Carlos III Health Institute, Madrid, Spai;Miguel Servet Ophthalmology Research Group (GIMSO), University of Zaragoza, Aragon Health Research Institute (IIS Aragon), Zaragoza, Spai;Miguel Servet Ophthalmology Research Group (GIMSO), University of Zaragoza, Aragon Health Research Institute (IIS Aragon), Zaragoza, Spai;Department of Pathology, Lozano Blesa University Hospital, Zaragoza, Spai;National Ocular Pathology Network (OFTARED), Carlos III Health Institute, Madrid, Spai;Complutense University of Madrid. Innovation, Therapy and Pharmaceutical Development in Ophthalmology (InnOftal) Research Group, UCM 920415, Department of Pharmaceutics and Food Technology, Faculty of Pharmacy, Complutense University of Madrid, Spai;Health Research Institute, San Carlos Clinical Hospital (IdISSC), Madrid, Spai;

关键词: Glaucoma;    animal model;    PLGA microspheres;    neurodegeneration;    dexamethasone;   

DOI  :  10.1080/10717544.2021.1998245

来源: Taylor & Francis

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