Synthesization and characterization of poly(lactic-co-glycolic acid) / calcium phosphate bone cement from crab shells

7th International Conference on Key Engineering Materials

材料科学;工业技术

Abdul Hanan, M.R.^1 ; Daud, N.M.^1 ; Ismail, L.H.^1 ; Saidin, S.^1

Faculty of Biosciences and Medical Engineering, Universiti Teknologi Malaysia, UTM Johor Bahru, Johor

81310, Malaysia^1

关键词: Bone integration;    Cement solidifications;    Contact angle analysis;    Materials degradation;    Osteoconductive properties;    PLGA microspheres;    Poly lactic-co-glycolic acid;    Wet chemical route;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/201/1/012010/pdf
DOI  :  10.1088/1757-899X/201/1/012010

来源: IOP

【 摘 要 】

An injectable calcium phosphate (CaP) bone cement has been widely used for musculoskeletal and bone disorder due to its biocompatible and osteoconductive properties. In this study, CaP was successfully synthesized from crab shells by a wet chemical route. Poly(lactic-co-glycolic acid) (PLGA) microspheres which have been produced through a double emulsion technique were incorporated into the CaP mixture for the purpose of bone cement solidification. The ratio of both compounds, CaP and PLGA, were set at 8:2. The CaP and PLGA/CaP bone cement were analyzed by ATR-FTIR, FESEM-EDX and contact angle analyses. The bone cement was composed of CaP and PLGA where the micro-powders of CaP were agglomerated on the PLGA microspheres. Addition of the PLGA has increased the hydrophilicity of the bone cement which will be beneficial for materials degradation and bone integration.