Shorter incubation period is associated with severe disease progression in patients with COVID-19

Virulence

Zhiwei Li¹  Guohong Deng²  Rentao Yu³  Zhiyu Li⁴  Xuan Li⁴  Wenjie Xian⁴  Qiyuan Tang⁴  Ruikun Chen⁴  Xin Zhao⁴  Xuan Zhou⁴  Fang Wang⁴  Mingbo Wang⁴  Changxiang Lai⁴ 

[1] Department of Hepatobiliary Surgery, The Third People’s Hospital of Shenzhen, National Clinical Research Center for Infectious Disease, the Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, Guangdong, Chin;Department of Infectious Diseases, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, Chin;Department of Infectious Diseases, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, Chin;Department of Infectious Diseases, The General Hospital of Western Theater Command, Chengdu, Sichuan, Chin;Department of Liver Diseases, The Third People’s Hospital of Shenzhen, National Clinical Research Center for Infectious Disease, the Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, Guangdong, Chin;

关键词: incubation period;    COVID-19;    SARS-CoV-2;    disease aggravation;    CT scores;   

DOI  :  10.1080/21505594.2020.1836894

来源: Taylor & Francis

【 摘 要 】

The diagnosed COVID-19 cases revealed that the incubation periods (IP) varied a lot among patients. However, few studies had emphasized on the different clinical features and prognosis of patients with different IP. A total of 330 patients with laboratory-confirmed COVID-19 were enrolled and classified into immediate onset group(IP<3 days, I group, 57 cases) and late onset group(IP>10 days, L group, 75 cases) based on IP. The difference of clinical characteristics and prognosis of the two groups were compared. There were more patients with fever in I group than in L group(P = 0.003), and counts of all the total lymphocytes, total T lymphocytes, CD4 + and CD8 + T lymphocytes were significantly different between the two groups(all P < 0.01). Besides, patients in L group had more GGOs in CT scan than I group and there were more patients in I group receiving antibiotic treatment than in L group(P < 0.001). For disease aggravation, the median CT scores were comparable between the two groups, but individually, there were more patients with increased CT score during hospitalization in I group than in L group. The aggravation incidence of CT presentation was 21.1% in I group, significantly higher than L group(8.0%, P = 0.042). Multivariable COX models suggested that IP was the only independent factors for CT aggravation. Conclusively, patients with different IP were different in clinical symptoms, laboratory tests, and CT presentations. Shorter IP was associated with the aggravation of lung involvement in CT scan.

【 授权许可】

CC BY