Supraphysiological estradiol promotes human T follicular helper cell differentiation and favours humoural immunity during in vitro fertilization

Journal of Cellular and Molecular Medicine

Xiuying Lin¹  Cong Hu²  Bo Pang³  Huanfa Yi⁴  Yu Zhen⁵  Hao Wu⁶  HongLei Liu⁷ 

[1] Center for Reproductive Medicine, Jilin Province People's Hospital, Changchun, China;Central Laboratory, The First Hospital of Jilin University, Changchun, China;Center for Reproductive Medicine, Center for Prenatal Diagnosis, The First Hospital of Jilin University, Changchun, China;Central Laboratory, The First Hospital of Jilin University, Changchun, China;Department of Cardiology, The First Hospital of Jilin University, Changchun, China;Central Laboratory, The First Hospital of Jilin University, Changchun, China;Key Laboratory of Organ Regeneration and Transplantation, Ministry of Education, Changchun, China;Department of Dermatology and Venerology, The First Hospital of Jilin University, Changchun, China;Key Laboratory of Organ Regeneration and Transplantation, Ministry of Education, Changchun, China;Department of Nephrology, The First Hospital of Jilin University, Changchun, China;Department of Rheumatology and Immunology, Shanghai Jiao Tong University School of Medicine Affiliated Ruijin Hospital, Shanghai, China;

关键词: B cells;    estradiol;    humoural immunity;    in vitro fertilization;    T follicular helper cells;   

DOI  :  10.1111/jcmm.16651

来源: Wiley

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