REST/NRSF deficiency impairs autophagy and leads to cellular senescence in neurons

Aging Cell

Jagoda Aleksandra Kowalska¹  Emanuele Carminati²  Anna Rocchi³  Fabio Benfenati³  Antonio De Fusco³  Thomas Floss⁴ 

[1] Center for Synaptic Neuroscience and Technology, Istituto Italiano di Tecnologia, Genova, Italy;Center for Synaptic Neuroscience and Technology, Istituto Italiano di Tecnologia, Genova, Italy;Department of Experimental Medicine, University of Genova, Genova, Italy;Center for Synaptic Neuroscience and Technology, Istituto Italiano di Tecnologia, Genova, Italy;IRCCS, Ospedale Policlinico San Martino, Genova, Italy;Helmholtz Zentrum München, Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH), Neuherberg, Germany;

关键词: autophagy;    mitochondria;    neurons;    oxidative stress;    rapamycin;    REST/NRSF;    senescence;    trehalose;   

DOI  :  10.1111/acel.13471

来源: Wiley

【 授权许可】

CC BY