Prompt Reduction in CRP, IL-6, IFN-γ, IP-10, and MCP-1 and a Relatively Low Basal Ratio of Ferritin/CRP Is Possibly Associated With the Efficacy of Tocilizumab Monotherapy in Severely to Critically Ill Patients With COVID-19

Frontiers in Medicine

Kazuyuki Yoshizaki¹  Emi Nakayama²  Tatsuo Shioda²  Kazuko Uno³  Yasunari Tsuchihashi³  Mitsuhiro Iwahashi⁴  Takayuki Nagai⁵  Makoto Kameda⁵  Heita Kitajima⁵  Tsuyoshi Arai⁵  Hiroshi Morishita⁵  Yuki Han⁵  Tomonori Hirashima⁵  Toshio Tanaka⁵  Yoshitaka Tamura⁵  Tomoki Yamada⁵  Seiji Yamaguchi⁵  Shoji Hashimoto⁵  Hiroto Matsuoka⁵  Yozo Kashiwa⁵  Seijiro Minamoto⁵ 

[1] Department of Organic Fine Chemicals, Institute of Scientific and Industry Research, Osaka University, Osaka, Japan;Department of Viral Infection, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan;Division of Basic Research, Louis Pasteur Center for Medical Research, Kyoto, Japan;Higashi Hiroshima Memorial Hospital, Hiroshima, Japan;Osaka Prefectural Hospital Organization Osaka Habikino Medical Center, Osaka, Japan;

关键词: COVID-19;    cytokine storm;    IL-6;    tocilizumab;    dexamethasone;   

DOI  :  10.3389/fmed.2021.734838

来源: Frontiers

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