Expression and prognostic significance of Niemann-Pick C1-Like 1 in colorectal cancer: a retrospective cohort study

Lipids in Health and Disease

Chungsu Hwang¹  Choongrak Kim²  Ryuk Jun Kwon³  Youngin Lee³  Eun-Ju Park³  Sang Yeoup Lee³  Young Hye Cho³ 

[1] Department of Pathology, Pusan National University School of Medicine, 626-780, Yangsan, South Korea;Department of Statistics, Pusan National University, 609-735, Busan, South Korea;Family Medicine Clinic and Research Institute of Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Beomeo-ri, Mulgeum-eup, 50612, Yangsan, Gyeongsangnam-do, South Korea;

关键词: Niemann-Pick C1-Like 1;    Ezetimibe;    Cholesterol;    Colorectal cancer;    Prognosis;    Overall survival;    Stage;    Molecular marker;   

DOI  :  10.1186/s12944-021-01539-0

来源: Springer

【 摘 要 】

BackgroundColorectal cancer (CRC) is a malignancy of the large intestine, whose development and prognosis have been demonstrated to be associated with altered lipid metabolism. High cholesterol intake is associated with an increased risk of CRC, and elevated serum cholesterol levels are known to be correlated with risk of developing CRC. Niemann-Pick C1-Like 1 (NPC1L1), a target of ezetimibe, plays an essential role in the absorption of intestinal cholesterol. However, whether the altered expression of NPC1L1 affects CRC development and prognosis is currently unknown.MethodsData corresponding to patients with CRC were obtained from The Cancer Genome Atlas (TCAG). Datasets from the Genome Data Analysis Center (GDAC) platform were analyzed to compare the expression of NPC1L1 in normal and CRC tissues using the Mann–Whitney U test and chi-square test. Further, the datasets from the Gene Expression Omnibus (GEO) database were analyzed. The log-rank test and multivariate Cox proportional hazard regression analysis were performed to determine whether NPC1L1 significantly affects the prognosis of CRC.ResultsThe expression of NPC1L1 was found to be upregulated in CRC and was significantly associated with the N and pathological stages but not with the histological type, age, and sex. Increased NPC1L1 expression in CRC was related to poor patient survival, as evidenced by the Kaplan–Meier and multivariate regression analyses.ConclusionsAs high expression of NPC1L1 was associated with CRC development, pathological stage, and prognosis, NPC1L1 can serve as an independent prognostic marker for CRC.

【 授权许可】

CC BY