RNA sequencing of blood in coronary artery disease: involvement of regulatory T cell imbalance

BMC Medical Genomics

Dmitry Shtakalo¹  Denis Antonets¹  Yinglei Lai²  Jonathan Reiner³  Ramesh Mazhari³  Ju H. Kim³  Richard Katz³  Justin Ertle⁴  Richard Wargodsky⁴  Zhaoquing Yang⁴  Zachary Falk⁴  Emily Aledort⁴  Zeynep Arslan⁴  Maha Alfaraidy⁴  Ian Toma⁵  Timothy A. McCaffrey⁶  Palak Shah⁷  Michael Tackett⁸  Dan Jones⁸  Tisha Jepson⁹  Georges St. Laurent^1,10 

[1] A.P. Ershov Institute of Informatics Systems SB RAS, 6, Acad. Lavrentjeva Ave, 630090, Novosibirsk, Russia;Department of Statistics, Biostatistics Center, The George Washington University, 20037, Washington, DC, USA;Division of Cardiology, Department of Medicine, The George Washington University, 20037, Washington, DC, USA;Division of Genomic Medicine, Department of Medicine, The George Washington Medical Center, The George Washington University, 2300 I Street NW, Ross Hall 443A, 20037, Washington, DC, USA;Division of Genomic Medicine, Department of Medicine, The George Washington Medical Center, The George Washington University, 2300 I Street NW, Ross Hall 443A, 20037, Washington, DC, USA;Department of Clinical Research and Leadership, The George Washington University, 20037, Washington, DC, USA;True Bearing Diagnostics, 20037, Washington, DC, USA;Division of Genomic Medicine, Department of Medicine, The George Washington Medical Center, The George Washington University, 2300 I Street NW, Ross Hall 443A, 20037, Washington, DC, USA;The St. Laurent Institute, Vancouver, WA, USA;Department of Microbiology, Immunology, and Tropical Medicine, The George Washington University, 20037, Washington, DC, USA;True Bearing Diagnostics, 20037, Washington, DC, USA;Inova Heart and Vascular Institute, Fairfax, VA, USA;SeqLL, Inc., Woburn, MA, USA;SeqLL, Inc., Woburn, MA, USA;The St. Laurent Institute, Vancouver, WA, USA;True Bearing Diagnostics, 20037, Washington, DC, USA;The St. Laurent Institute, Vancouver, WA, USA;

关键词: Atherosclerosis;    Transcriptome;    RNA sequencing;    Regulatory T cells;    Treg;    FoxP1;    FoxP3;    Biomarker;    Coronary artery disease;    Stress granules;    Cilia;    Immune synapse;   

DOI  :  10.1186/s12920-021-01062-2

来源: Springer

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