Cellular reprogramming and epigenetic rejuvenation

Clinical Epigenetics

Nelly N. Olova¹  Tamir Chandra¹  Daniel J. Simpson¹ 

[1] MRC Human Genetics Unit, MRC Institute of Genetics and Cancer, University of Edinburgh, EH4 2XU, Edinburgh, UK;

关键词: Cellular reprogramming;    Ageing;    Rejuvenation;    Epigenetic clocks;    Transient reprogramming;    Reprogramming-induced rejuvenation;    Epigenetic age;   

DOI  :  10.1186/s13148-021-01158-7

来源: Springer

【 摘 要 】

Ageing is an inevitable condition that afflicts all humans. Recent achievements, such as the generation of induced pluripotent stem cells, have delivered preliminary evidence that slowing down and reversing the ageing process might be possible. However, these techniques usually involve complete dedifferentiation, i.e. somatic cell identity is lost as cells are converted to a pluripotent state. Separating the rejuvenative properties of reprogramming from dedifferentiation is a promising prospect, termed epigenetic rejuvenation. Reprogramming-induced rejuvenation strategies currently involve using Yamanaka factors (typically transiently expressed to prevent full dedifferentiation) and are promisingcandidates to safely reduce biological age. Here, we review the development and potential of reprogramming-induced rejuvenation as an anti-ageing strategy.

【 授权许可】

CC BY