Ageing and rejuvenation models reveal changes in key microbial communities associated with healthy ageing

Microbiome

Yoseb Song¹  Byung-Kwan Cho¹  Jongoh Shin¹  Namil Lee¹  Donghui Choe¹  Suhyung Cho¹  Haiyoung Jung²  Byoung-Chan Kim³  Jae-Hoon Kim⁴  Chul-Ho Lee⁴  Kyoung-Shim Kim⁴  Seok Kyun Ha⁴  Min-Jeong Go⁴  Yong-Hoon Kim⁴  Jung-Ran Noh⁴  Eun-Jung Kang⁴  Dong-Ho Chang⁵  Myung Hee Kim⁵  Bong-Hyun Sung⁶  Seung-Goo Lee⁶  Dae-Hee Lee⁶ 

[1] Department of Biological Sciences and KI for the BioCentury, Korea Advanced Institute of Science and Technology, 34141, Daejeon, Republic of Korea;Immunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology, 34141, Daejeon, Republic of Korea;Immunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology, 34141, Daejeon, Republic of Korea;Healthbiome Co., Ltd., 34141, Daejeon, Republic of Korea;Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology, 34141, Daejeon, Republic of Korea;Metabolic Regulation Research Center, Korea Research Institute of Bioscience and Biotechnology, 34141, Daejeon, Republic of Korea;Synthetic Biology & Bioengineering Research Center, Korea Research Institute of Bioscience and Biotechnology, 34141, Daejeon, Korea;

关键词: Ageing;    Rejuvenation;    Akkermansia muciniphila;    Shotgun metagenomics;    16s rRNA sequencing;   

DOI  :  10.1186/s40168-021-01189-5

来源: Springer

【 摘 要 】

BackgroundThe gut microbiota is associated with diverse age-related disorders. Several rejuvenation methods, such as probiotic administration and faecal microbiota transplantation, have been applied to alter the gut microbiome and promote healthy ageing. Nevertheless, prolongation of the health span of aged mice by remodelling the gut microbiome remains challenging.ResultsHere, we report the changes in gut microbial communities and their functions in mouse models during ageing and three rejuvenation procedures including co-housing, serum-injection and parabiosis. Our results showed that the compositional structure and gene abundance of the intestinal microbiota changed dynamically during the ageing process. Through the three rejuvenation procedures, we observed that the microbial community and intestinal immunity of aged mice were comparable to those of young mice. The results of metagenomic data analysis underscore the importance of the high abundance of Akkermansia and the butyrate biosynthesis pathway in the rejuvenated mouse group. Furthermore, oral administration of Akkermansia sufficiently ameliorated the senescence-related phenotype in the intestinal systems in aged mice and extended the health span, as evidenced by the frailty index and restoration of muscle atrophy.ConclusionsIn conclusion, the changes in key microbial communities and their functions during ageing and three rejuvenation procedures, and the increase in the healthy lifespan of aged mice by oral administration of Akkermansia. Our results provide a rationale for developing therapeutic strategies to achieve healthy active ageing.DWzth9x4bNysC3Pe8t3wT_Video abstract

【 授权许可】

CC BY