Characteristics of epigenetic aging across gestational and perinatal tissues

Clinical Epigenetics

Pia M. Villa¹  Jari Lahti²  Katri Raikkönen²  Tuomas Kvist²  Marius Lahti-Pulkkinen³  Sara Sammallahti⁴  Cristiana Cruceanu⁵  Darina Czamara⁵  Elisabeth B. Binder⁶  Linda Dieckmann⁷  Hannele Laivuori⁸  Sanna Suomalainen-König⁹  Johan G. Eriksson^1,10  Eero Kajantie^1,11  Peter E. DeWitt^1,12 

[1] Department of Obstetrics and Gynecology- Faculty of Medicine and Health Technology, Tampere University Hospital and Tampere University, Tampere, Finland;Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland;Hyvinkää Hospital, Helsinki and Uusimaa Hospital District, Hyvinkää, Finland;Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland;Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland;National Institute for Health and Welfare, Helsinki, Finland;Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK;Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland;National Institute for Health and Welfare, Helsinki, Finland;Children’s Hospital, Helsinki University Hospital and University of Helsinki, Helsinki, Finland;Department of Child and Adolescent Psychiatry, Erasmus MC, Sophia Children’s Hospital, Rotterdam, The Netherlands;Department of Translational Psychiatry, Max Planck Institute of Psychiatry, München, Germany;Department of Translational Psychiatry, Max Planck Institute of Psychiatry, München, Germany;Department of Psychiatry and Behavioral Sciences, School of Medicine, Emory University, Atlanta, GA, USA;Department of Translational Psychiatry, Max Planck Institute of Psychiatry, München, Germany;International Max Planck Research School for Translational Psychiatry, München, Germany;Institute for Molecular Medicine Finland, HiLIFE, University of Helsinki, Human Genetics, Helsinki, Finland;Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland;Department of Obstetrics and Gynecology- Faculty of Medicine and Health Technology, Tampere University Hospital and Tampere University, Tampere, Finland;Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland;Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland;Folkhälsan Research Center, Helsinki, Finland;Department of Obstetrics & Gynaecology and Human Potential Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore;Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore;National Institute for Health and Welfare, Helsinki, Finland;Children’s Hospital, Helsinki University Hospital and University of Helsinki, Helsinki, Finland;Faculty of Medicine, PEDEGO Research Unit, MRC Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland;Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway;Section of Informatics and Data Science, Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO, USA;

关键词: Epigenetic clocks;    Early development;    Epigenetic age;    Perinatal tissues;    Cord blood;    Placenta;    Chorionic villi;   

DOI  :  10.1186/s13148-021-01080-y

来源: Springer

【 摘 要 】

BackgroundEpigenetic clocks have been used to indicate differences in biological states between individuals of same chronological age. However, so far, only few studies have examined epigenetic aging in newborns—especially regarding different gestational or perinatal tissues. In this study, we investigated which birth- and pregnancy-related variables are most important in predicting gestational epigenetic age acceleration or deceleration (i.e., the deviation between gestational epigenetic age estimated from the DNA methylome and chronological gestational age) in chorionic villus, placenta and cord blood tissues from two independent study cohorts (ITU, n = 639 and PREDO, n = 966). We further characterized the correspondence of epigenetic age deviations between these tissues.ResultsAmong the most predictive factors of epigenetic age deviations in single tissues were child sex, birth length, maternal smoking during pregnancy, maternal mental disorders until childbirth, delivery mode and parity. However, the specific factors related to epigenetic age deviation and the direction of association differed across tissues. In individuals with samples available from more than one tissue, relative epigenetic age deviations were not correlated across tissues.ConclusionGestational epigenetic age acceleration or deceleration was not related to more favorable or unfavorable factors in one direction in the investigated tissues, and the relative epigenetic age differed between tissues of the same person. This indicates that epigenetic age deviations associate with distinct, tissue specific, factors during the gestational and perinatal period. Our findings suggest that the epigenetic age of the newborn should be seen as a characteristic of a specific tissue, and less as a general characteristic of the child itself.

【 授权许可】

CC BY