Bisphenol-A exposure and risk of breast and prostate cancer in the Spanish European Prospective Investigation into Cancer and Nutrition study

Environmental Health

Elena Salamanca-Fernández¹  Miguel Rodríguez-Barranco²  Maria-José Sánchez³  Maria Dolores Chirlaque⁴  Sandra Colorado⁵  Josu Delfrade⁶  Marcela Guevara⁶  Pilar Amiano⁷  Fernando Vela⁸  Juan Pedro Arrebola⁹  Nicolás Olea^1,10  Ana Jimenez^1,11  Antonio Agudo^1,12 

[1] Andalusian School of Public Health (EASP), Campus Universitario de Cartuja, C/Cuesta del Observatorio 4, 18080, Granada, Spain;Instituto de Investigación Biosanitaria ibs. GRANADA, Granada, Spain;Andalusian School of Public Health (EASP), Campus Universitario de Cartuja, C/Cuesta del Observatorio 4, 18080, Granada, Spain;Instituto de Investigación Biosanitaria ibs. GRANADA, Granada, Spain;CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain;Andalusian School of Public Health (EASP), Campus Universitario de Cartuja, C/Cuesta del Observatorio 4, 18080, Granada, Spain;Instituto de Investigación Biosanitaria ibs. GRANADA, Granada, Spain;CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain;Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain;CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain;Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain;Department of Health and Sciences, University of Murcia, Murcia, Spain;CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain;Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain;Research Group on Demography and Health, National Faculty of Public Health, University of Antioquia, Medellín, Colombia;CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain;Navarra Public Health Institute, Pamplona, Spain;Navarra Institute for Health Research (IdiSNA), Pamplona, Spain;CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain;Public Health Division of Gipuzkoa, BioDonostia Research Institute, Donostia-San Sebastian, Spain;Instituto de Investigación Biosanitaria ibs. GRANADA, Granada, Spain;Instituto de Investigación Biosanitaria ibs. GRANADA, Granada, Spain;CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain;Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain;Instituto de Investigación Biosanitaria ibs. GRANADA, Granada, Spain;CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain;Department of Radiology, University of Granada, Granada, Spain;Public Health Division of Gipuzkoa, BioDonostia Research Institute, Donostia-San Sebastian, Spain;Unit of Nutrition and Cancer, Catalan Institute of Oncology - ICO, Nutrition and Cancer Group, Bellvitge Biomedical Research Institute - IDIBELL, L’Hospitalet de Llobregat, 08908, Barcelona, Spain;

关键词: Breast cancer;    Prostate cancer;    Case-cohort;    Bisphenol a;    Environmental pollutants;   

DOI  :  10.1186/s12940-021-00779-y

来源: Springer

【 摘 要 】

BackgroundBisphenol A (BPA) is an endocrine disruptor that it is present in numerous products of daily use. The aim of this study was to assess the potential association of serum BPA concentrations and the risk of incident breast and prostate cancer in a sub-cohort of the Spanish European Prospective Investigation into Cancer and Nutrition (EPIC).MethodsWe designed a case-cohort study within the EPIC-Spain cohort. Study population consisted on 4812 participants from 4 EPIC-Spain centers (547 breast cancer cases, 575 prostate cancer cases and 3690 sub-cohort participants). BPA exposure was assessed by means of chemical analyses of serum samples collected at recruitment. Borgan II weighted Cox regression was used to estimate hazard ratios.ResultsMedian follow-up time in our study was 16.9 years. BPA geometric mean serum values of cases and sub-cohort were 1.12 ng/ml vs 1.10 ng/ml respectively for breast cancer and 1.33 ng/ml vs 1.29 ng/ml respectively for prostate cancer. When categorizing BPA into tertiles, a 40% increase in risk of prostate cancer for tertile 1 (p = 0.022), 37% increase for tertile 2 (p = 0.034) and 31% increase for tertile 3 (p = 0.072) was observed with respect to values bellow the limit of detection. No significant association was observed between BPA levels and breast cancer risk.ConclusionsWe found a similar percentage of detection of BPA among cases and sub-cohort from our population, and no association with breast cancer risk was observed. However, we found a higher risk of prostate cancer for the increase in serum BPA levels. Further investigation is needed to understand the influence of BPA in prostate cancer risk.

【 授权许可】

CC BY