Investigating novel biomarkers of immune activation and modulation in the context of sedentary behaviour: a multicentre prospective ischemic stroke cohort study

BMC Neurology

Per-Magne Ueland¹  Arve Ulvik¹  Jörg Assmus²  Anne-Brita Knapskog³  Tom Eirik Mollnes⁴  Mala Naik⁵  Torunn Askim⁶  Ingvild Saltvedt⁷  Katinka Nordheim Alme⁸  Halvor Næss⁹ 

[1] Bevital AS, Bergen, Norway;Centre for Clinical Research, Haukeland University Hospital, Bergen, Norway;Department of Geriatric Medicine, Oslo University Hospital, Ullevaal, Oslo, Norway;Department of Immunology, Oslo University Hospital and University of Oslo, Oslo, Norway;Research Laboratory, Nordland Hospital, Bodø, and K.G. Jebsen TREC, University of Tromsø, Tromsø, Norway;Centre of Molecular Inflammation Research, Norwegian University of Science and Technology, Trondheim, Norway;Department of Internal Medicine, Haraldsplass Deaconess Hospital, Bergen, Norway;Department of Clinical Science (K2), University of Bergen, Bergen, Norway;Department of Neuromedicine and Movement Science, Faculty of Medicine and Health Science, NTNU-Norwegian University of Science and Technology, Trondheim, Norway;Department of Neuromedicine and Movement Science, Faculty of Medicine and Health Science, NTNU-Norwegian University of Science and Technology, Trondheim, Norway;Department of Geriatrics, Clinic of internal medicine, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway;Institute of Clinical Medicine (K1), University of Bergen, Bergen, Norway;Department of Internal Medicine, Haraldsplass Deaconess Hospital, Bergen, Norway;Institute of Clinical Medicine (K1), University of Bergen, Bergen, Norway;Department of Neurology, Haukeland University Hospital, Bergen, Norway;Centre for age-related medicine, Stavanger University Hospital, Stavanger, Norway;

关键词: Sedentary behavior;    Inflammation;    Immune modulation;    Vascular disease;    Kynurenine pathway;    Stroke;   

DOI  :  10.1186/s12883-021-02343-0

来源: Springer

【 摘 要 】

BackgroundSedentary behaviour is associated with disease, but the molecular mechanisms are not understood. Valid biomarkers with predictive and explanatory properties are required. Therefore, we have investigated traditional and novel biomarkers of inflammation and immune modulation and their association to objectively measured sedentary behaviour in an ischemic stroke population.MethodsPatients admitted to hospital with acute ischemic stroke were included in the multicentre Norwegian Cognitive Impairment After Stroke (Nor-COAST) study (n = 815). For this sub-study (n = 257), sedentary behaviour was registered 3 months after stroke using position transition data from the body-worn sensor, ActivPal®. Blood samples were analysed for high sensitive C-reactive protein (hsCRP), the cytokines interleukin-6 (IL-6) and 10 (IL-10), neopterin, tryptophan (Trp), kynurenine (kyn), kynurenic acid (KA), and three B6 vitamers, pyridoxal 5′-phosphate (PLP), pyridoxal (PL), and pyridoxic acid (PA). The kynurenine/tryptophan ratio (KTR) and the pyridoxic acid ratio index (PAr = PA: PL + PLP) were calculated.ResultsOf the 815 patients included in the main study, 700 attended the three-month follow-up, and 257 fulfilled the inclusion criteria for this study. Sedentary time was significantly associated with levels of hsCRP, IL-6, neopterin, PAr-index, and KA adjusted for age, sex, waist circumference, and creatinine. In a fully adjusted model including all the significant biomarkers except hsCRP (because of missing values), sedentary time was independently positively associated with the PAr-index and negatively with KA. We did not find an association between sedentary behaviour, IL-10, and KTR.ConclusionsThe PAr-index is known to capture several modes of inflammation and has previously shown predictive abilities for future stroke. This novel result indicates that the PAr-index could be a useful biomarker in future studies on sedentary behaviour and disease progression. KA is an important modulator of inflammation, and this finding opens new and exciting pathways to understand the hazards of sedentary behaviour.Trial registrationThe study was registered at Clinicaltrials.gov (NCT02650531). First posted 08/01/2016.

【 授权许可】

CC BY