Lactobacillus helveticus suppresses experimental rheumatoid arthritis by reducing inflammatory T cell responses

Journal of Functional Foods

Young Kim¹  Chang Suk Chae¹  Ji-sun Hwang¹  Gi-Cheon Kim²  Sung-Gyoo Park²  Young-Tae Ahn²  Chang-Duk Jun³  Dipayan Rudra⁴  Sung-Min Hwang⁵  Won Hwang⁵  Sin-Hyeog Im⁵  Jung-Eun Kim⁵ 

[1] Academy of Immunology and Microbiology (AIM), Institute for Basic Science (IBS), Pohang, Republic of Korea;Academy of Immunology and Microbiology (AIM), Institute for Basic Science (IBS), Pohang, Republic of Korea;Chonnam National University Medical School, Gwangju 501-749, Republic of Korea;R&BD Center, Korea Yakult Co. Ltd., Yongin 446-901, Republic of Korea;School of Life Sciences, Gwangju Institute of Science and Technology (GIST), 261 Cheomdan-gwagiro, Buk-gu, Gwangju 500-712, Republic of Korea;

关键词: Cytokine;    Inflammation;    Immune modulation;    Probiotics;    Rheumatoid arthritis;   

DOI  :  

来源: DOAJ

【 摘 要 】

Although probiotics could confer health benefits to host physiology, their efficacy is strain specific. To identify anti-inflammatory probiotics, an ex vivo screening system was developed, and validated effector functions of selected candidates using experimental rheumatoid arthritis as an in vivo model. Lactobacillus helveticus HY7801 was selected as the best candidate. Oral administration of L. helveticus HY7801 prevented the development of collagen-induced experimental arthritis, and diminished disease progression and severity by reducing antigen specific IgG levels and inflammatory immune response. Administration of L. helveticus HY7801 may induce regulatory CD11c+ dendritic cells, which in turn induce a phenotypic alteration of immune cells by reducing pro-inflammatory cytokines (TNF-α, IFN-γ, and IL-17A) while enhancing anti-inflammatory cytokine (IL-10) by CD4+ T cells. This study suggests that screening of probiotic strains based on the IL-10highIL-12low selection criterion may be applicable to identify anti-inflammatory probiotics as an efficacious food for treating inflammatory immune responses including rheumatoid arthritis.

【 授权许可】

Unknown