Mesenchymal stem cell-based therapy and exosomes in COVID-19: current trends and prospects

Stem Cell Research & Therapy

Mai Abdelgawad¹  Ahmed Lotfy¹  Nourhan Saied Bakry¹  Ahmed Abdel-Latif²  Ahmed A. Farghali³ 

[1] Biotechnology and Life Sciences Department, Faculty of Postgraduate Studies for Advanced Sciences (PSAS), Beni-Suef University, 62511, Beni Suef, Egypt;Gill Heart Institute and Division of Cardiovascular Medicine, University of Kentucky and the Lexington VA Medical Center, Lexington, KY, USA;College of Medicine, University of Kentucky, 40506-0046, Lexington, KY, USA;Materials Science and Nanotechnology Department, Faculty of Postgraduate Studies for Advanced Sciences (PSAS), Beni-Suef University, 62511, Beni Suef, Egypt;

关键词: Mesenchymal stem cell;    Mesenchymal stromal cell;    Exosomes;    COVID-19;    Immunomodulation;    Cytokine storm;    SARS-CoV-2;   

DOI  :  10.1186/s13287-021-02542-z

来源: Springer

【 摘 要 】

Novel coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus-2. The virus causes an exaggerated immune response, resulting in a cytokine storm and acute respiratory distress syndrome, the leading cause of COVID-19-related mortality and morbidity. So far, no therapies have succeeded in circumventing the exacerbated immune response or cytokine storm associated with COVID-19. Mesenchymal stem cells (MSCs), through their immunomodulatory and regenerative activities, mostly mediated by their paracrine effect and extracellular vesicle production, have therapeutic potential in many autoimmune, inflammatory, and degenerative diseases. In this paper, we review clinical studies on the use of MSCs for COVID-19 treatment, including the salutary effects of MSCs on the pathophysiology of COVID-19 and the immunomodulation of the cytokine storm. Ongoing clinical trial designs, cell sources, dose and administration, and populations are summarized, and the paracrine mode of benefit is discussed. We also offer suggestions for optimizing MSC-based therapies, including genetic engineering, strategies for cell surface modification, nanotechnology applications, and combination therapies.

【 授权许可】

CC BY