Stem cell therapies for autoimmune hepatitis

Stem Cell Research & Therapy

Ahmed Lotfy¹  Aya Elgamal²  Anna Burdzinska³  Ayman A. Swelum⁴  Ayman A. Hassan⁵  Gamal Shiha⁶  Reham Soliman⁷ 

[1] Biotechnology and Life Sciences Department, Faculty of Postgraduate Studies for Advanced Sciences (PSAS), Beni-Suef University, 62511, Beni-Suef, Egypt;Department of Animal Histology and Anatomy, Faculty of Veterinary Medicine, Badr University in Cairo (BUC), Cairo, Egypt;Department of Immunology, Transplantology and Internal Diseases, Medical University of Warsaw, Nowogrodzka 59, 02-006, Warsaw, Poland;Department of Theriogenology, Faculty of Veterinary Medicine, Zagazig University, 44511, Zagazig, Egypt;Department of Animal Production, College of Food and Agriculture Sciences, King Saud University, 11451, Riyadh, Saudi Arabia;Egyptian Liver Research Institute and Hospital (ELRIAH), Mansoura, Egypt;Egyptian Liver Research Institute and Hospital (ELRIAH), Mansoura, Egypt;Hepatology and Gastroenterology Unit, Internal Medicine Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt;Tropical Medicine Department, Faculty of Medicine, Port Said University, Port Said, Egypt;Egyptian Liver Research Institute and Hospital (ELRIAH), Mansoura, Egypt;

关键词: Stem cells;    Autoimmune hepatitis;    Mesenchymal stem cell;    Hematopoietic stem cells;    Exosomes;    Mesenchymal stromal cell;   

DOI  :  10.1186/s13287-021-02464-w

来源: Springer

【 摘 要 】

Autoimmune hepatitis is a chronic inflammatory hepatic disorder which may cause liver fibrosis. Appropriate treatment of autoimmune hepatitis is therefore important. Adult stem cells have been investigated as therapies for a variety of disorders in latest years. Hematopoietic stem cells (HSCs) were the first known adult stem cells (ASCs) and can give rise to all of the cell types in the blood and immune system. Originally, HSC transplantation was served as a therapy for hematological malignancies, but more recently researchers have found the treatment to have positive effects in autoimmune diseases such as multiple sclerosis. Mesenchymal stem cells (MSCs) are ASCs which can be extracted from different tissues, such as bone marrow, adipose tissue, umbilical cord, and dental pulp. MSCs interact with several immune response pathways either by direct cell-to-cell interactions or by the secretion of soluble factors. These characteristics make MSCs potentially valuable as a therapy for autoimmune diseases. Both ASC and ASC-derived exosomes have been investigated as a therapy for autoimmune hepatitis. This review aims to summarize studies focused on the effects of ASCs and their products on autoimmune hepatitis.

【 授权许可】

CC BY