Kinetic and toxicological effects of synthesized palladium(II) complex on snake venom (Bungarus sindanus ) acetylcholinesterase

Journal of venomous animals and toxins

article

Mushtaq Ahmed¹  Shahan Zeb Khan²  Naila Sher¹  Zia Ur Rehman²  Nadia Mushtaq³  Rahmat Ali Khan¹ 

[1] Department of Biotechnology, University of Science and TechnologyBannu-KPK;Department of Chemistry, Quaid-i-Azam University;Department of Botany, University of Science and TechnologyBannu-KPK

关键词: Palladium (II) complex;    Snake venom;    Acetylcholinesterase;    Inhibition;    Kinetics;   

DOI  :  10.1590/1678-9199-JVATITD-2020-0047

学科分类：药理学

来源: BioMed Central

【 摘 要 】

Background: The venom of the krait ( Bungarus sindanus ), an Elapidae snake, is highly toxic to humans and contains a great amount of acetylcholinesterase (AChE). The enzyme AChE provokes the hydrolysis of substrate acetylcholine (ACh) in the nervous system and terminates nerve impulse. Different inhibitors inactivate AChE and lead to ACh accumulation and disrupted neurotransmission.

【 授权许可】

CC BY