Prognostic Value of N-Terminal Pro-B-Type Natriuretic Peptide and Glomerular Filtration Rate in Patients With Acute Heart Failure

Frontiers in Cardiovascular Medicine

article

Kai Wang¹  Wenming Yao¹  Haifeng Zhang¹  Xinli Li¹ 

[1] Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University

关键词: acute heart failure (AHF);    N-terminal pro-B-type natriuretic peptide (NT-proBNP);    glomerular filtration rate (GFR);    outcomes;    prognosis;   

DOI  :  10.3389/fcvm.2020.00123

学科分类：地球科学(综合)

来源: Frontiers

【 摘 要 】

Aims: To investigate the relationship between N-terminal pro-B-type natriuretic peptide (NT-proBNP), Glomerular Filtration Rate (GFR), and outcomes in patients hospitalized with acute heart failure (AHF). Methods: The trial was registered at http://www.chictr.org/cn/ . (ChiCTR – ONC - 12001944). A total of 493 patients hospitalized for AHF in cardiology department of the First Affiliated Hospital of Nanjing Medical University from March 2012 to October 2016 were enrolled into registry. The end event was the occurrence of all-cause death within an 18-month follow-up. The data collected from the participants in admission were used to calculate the GFR by chronic kidney disease epidemiology collaboration equation (CKD-EPI) and performed the according statistical analysis. Results: There were 74 participants (13.8%) dropped out and 91 (21.7%) passed away within the 18-month follow up. Comparison of clinical indicators between survival and death group were analyzed for the long-term prognosis of patients with AHF. In the single factor analysis, both NT-proBNP and GFR were statistically significant ( P 2,137 pg/ml and GFR < 61.7 ml/(min·1.73 m 2 ), the risk of death was significantly higher. The combination of GFR and NT-proBNP improved the predictive value for the long-term prognosis of AHF patients.

【 授权许可】

CC BY