Serum Clearance of Iodixanol for Estimating Glomerular Filtration Rate in Calves

Journal of Veterinary Medical Science

Kazuhisa FURUHAMA²  Norio YAMAGISHI¹  Shigeru SATO¹  Isao MURAYAMA³  Danil KIM¹  Bhuminand DEVKOTA¹  Kyoko IMAI² 

[1] Department of Veterinary Clinical Medicine, Iwate University;Department of Veterinary Basic Medicine, Iwate University;Miyagi Prefectural Federation of Agricultural Mutual Aid Associations

关键词: calves;    glomerular filtration rate (GFR);    iodixanol;    nephropathy;    serum clearance;   

DOI  :  10.1292/jvms.11-0252

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(17)Cited-By(1)To evaluate serum clearance of iodixanol, applicable to the estimation of glomerular filtration rate (GFR), clinically healthy and experimentally-induced nephropathy calves were prepared. Iodixanol was administered intravenously at 40 mg I/kg, and blood was withdrawn 60, 120, and 180 min later. Serum iodixanol concentration was determined by high-performance liquid chromatography. No statistical difference in GFR was noted between strains (Holstein vs. Japanese Black) or sexes, and the α2-adrenergic agonist xylazine increased GFR. In calves subjected to right renal vessel ligation, followed by a left nephrectomy, a marked reduction in GFR was observed with renal ischemic changes. These results suggest that the GFR estimation by serum iodixanol clearance is a ready-to-use tool in calf research and practice owing to the ease of monitoring serial renal function.

【 授权许可】

Unknown