Journal of Veterinary Medical Science | |
Serum Clearance of Iodixanol for Estimating Glomerular Filtration Rate in Calves | |
Kazuhisa FURUHAMA2  Norio YAMAGISHI1  Shigeru SATO1  Isao MURAYAMA3  Danil KIM1  Bhuminand DEVKOTA1  Kyoko IMAI2  | |
[1] Department of Veterinary Clinical Medicine, Iwate University;Department of Veterinary Basic Medicine, Iwate University;Miyagi Prefectural Federation of Agricultural Mutual Aid Associations | |
关键词: calves; glomerular filtration rate (GFR); iodixanol; nephropathy; serum clearance; | |
DOI : 10.1292/jvms.11-0252 | |
学科分类:兽医学 | |
来源: Japanese Society of Veterinary Science | |
【 摘 要 】
References(17)Cited-By(1)To evaluate serum clearance of iodixanol, applicable to the estimation of glomerular filtration rate (GFR), clinically healthy and experimentally-induced nephropathy calves were prepared. Iodixanol was administered intravenously at 40 mg I/kg, and blood was withdrawn 60, 120, and 180 min later. Serum iodixanol concentration was determined by high-performance liquid chromatography. No statistical difference in GFR was noted between strains (Holstein vs. Japanese Black) or sexes, and the α2-adrenergic agonist xylazine increased GFR. In calves subjected to right renal vessel ligation, followed by a left nephrectomy, a marked reduction in GFR was observed with renal ischemic changes. These results suggest that the GFR estimation by serum iodixanol clearance is a ready-to-use tool in calf research and practice owing to the ease of monitoring serial renal function.
【 授权许可】
Unknown
【 预 览 】
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RO201911300020315ZK.pdf | 728KB | download |