Sertraline Pharmacokinetics in HIV-Infected and Uninfected Children, Adolescents, and Young Adults

Frontiers in Pediatrics

article

Nathan John Hanan¹  Edmund V. Capparelli²  Brookie M. Best¹  Mary Elizabeth Paul³  Yanling Huo⁴  Suad Kapetanovic⁵  Elizabeth Smith⁶  George Siberry⁷  Pim Brouwers⁸  Bobbie Graham⁹  Benjamin Johnston⁹ 

[1] Department of Pediatrics-Rady Children's Hospital San Diego, University of California, United States;Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, United States;Department of Pediatrics, Baylor College of Medicine, United States;Center for Biostatistics in AIDS Research, Harvard T.H. Chan School of Public Health, United States;Department of Psychiatry, University of Southern California, United States;and Pediatric Research Branch, National Institute of Allergy and Infectious Diseases, United States;Maternal and Pediatric Infectious Disease Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, United States;Division of AIDS Research, National Institute of Mental Health, National Institutes of Health, United States;Frontier Science and Technology Research Foundation, United States

关键词: sertraline;    pharmacokinetics;    HIV;    pediatrics;    antiretrovirals;   

DOI  :  10.3389/fped.2019.00016

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Objective: Due to potential disease and drug interactions, the appropriate sertraline starting dose and titration range may require adjustment in pediatric patients living with HIV. This is the first report of sertraline pharmacokinetics in HIV-infected youth. Methods: IMPAACT P1080 was a multicenter pilot study describing psychiatric medication pharmacokinetics in HIV-infected and uninfected youth. Participants were stable on sertraline, >6 to -0.5). Conclusions: HIV(–) cohort had the highest sertraline exposure. Sertraline exposure was ~40% lower in the PI/r cohort than in HIV(–); the need to alter sertraline dose ranges for PI/r participants is not clear. The impact of efavirenz on sertraline needs further investigation due to limited numbers of EFV participants.

【 授权许可】

CC BY