Pre-pregnancy Maternal Weight and Gestational Weight Gain Increase the Risk for Childhood Asthma and Wheeze: An Updated Meta-Analysis

Frontiers in Pediatrics

article

Shufang Liu¹  Bo Zhou¹  Yunfeng Wang²  Kundi Wang²  Zhixin Zhang³  Wenquan Niu⁴ 

[1] Graduate School, Beijing University of Chinese Medicine;Department of Pediatrics, China-Japan Friendship Hospital;International Medical Services, China-Japan Friendship Hospital;Institute of Clinical Medical Sciences, China-Japan Friendship Hospital

关键词: asthma;    gestational weight gain;    meta-analysis;    maternal obesity;    maternal overweight;   

DOI  :  10.3389/fped.2020.00134

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Background: Mounting evidence suggests that childhood asthma is closely associated with maternal weight before pregnancy and gestational weight gain (GWG), yet the results are not often reproducible. Objectives: We conducted a comprehensive meta-analysis, aiming to evaluate the association of pre-pregnancy maternal obesity or overweight and high GWG with the risk for childhood asthma and wheeze. Methods: Literature search, quality assessment, and data extraction were completed independently and in duplicate. Effect-size estimates are expressed as odds ratio (OR) with 95% confidence interval (CI). Results: Twenty-two observational studies involving 145,574 mother-child pairs were meta-analyzed. In overall analyses, maternal obesity or overweight in pre-pregnancy significantly increased the risk of both childhood asthma and wheeze (adjusted OR: 1.41 and 1.13, 95% CI: 1.26–1.59 and 1.07–1.20, both p < 0.001). Per 1 kg/m 2 increment in maternal body mass index was associated with a significantly increased risk of childhood asthma and wheeze (adjusted OR: 1.03, 95% CI: 1.02-1.03, p < 0.001). Compared with normal GWG, very high GWG (adjusted OR: 1.24, 95% CI: 1.04-1.47, p : 0.018), moderate high GWG (adjusted OR: 1.12, 95% CI: 1.04-1.21, p : 0.004), and very low GWG (adjusted OR: 1.26, 95% CI: 1.08-1.47, p : 0.004) increased the risk of childhood asthma and wheeze. There was a low probability of publication bias. Conclusions: Our findings indicate that both pre-pregnancy maternal obesity or overweight and very to moderate high or low GWG render their offspring susceptible to a significantly increased risk of having childhood asthma and wheeze.

【 授权许可】

CC BY