Pre-Pregnancy Weight and Symptoms of Attention Deficit Hyperactivity Disorder and Executive Functioning Behaviors in Preschool Children

International Journal of Environmental Research and Public Health

Rachel Maguire¹  Cathrine Hoyo¹  BernardF. Fuemmeler²  Yaou Sheng²  Nancy Zucker³  CarmenE. Sanchez³  SusanK. Murphy³  ScottH. Kollins³ 

[1] Department of Biological Sciences, North Carolina State University, Raleigh, NC 27695, USA;Department of Health Behavior and Policy, Virginia Commonwealth University, Richmond, VA 23219, USA;Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27705, USA;

关键词: pregnancy;    gestational weight gain;    maternal obesity;    child development;    ADHD;   

DOI  :  10.3390/ijerph16040667

来源: DOAJ

【 摘 要 】

This study examines pre-pregnancy Body Mass Index (BMI) and gestational weight gain (GWG) in relation to early childhood Attention Deficit Hyperactivity Disorder (ADHD) symptoms and related executive self-regulation behaviors. The analyses sample (n = 331) included a subsample of participants from a birth cohort recruited from prenatal clinics and hospital facilities from April 2005 to June 2011 in Durham, North Carolina. Pre-pregnancy BMI was calculated from weight at the last menstrual period and height was extracted from medical records. Gestational weight gain was calculated from pre-pregnancy weight and weight measured at the time of delivery. ADHD symptoms and executive self-regulation behaviors were assessed by maternal report (mean age = 3 years). Multivariable regression methods with inverse probability weighting (IPW) were used to evaluate associations accounting for sample selection bias and confounding. Pre-pregnancy BMI at levels ≥35 was positively associated with higher ADHD symptoms and worse executive self-regulation behaviors (inhibitory control and attention). Compared to adequate GWG, less than adequate GWG was related to more ADHD hyperactive-impulsive symptoms, whereas greater than adequate GWG was related to more problematic behaviors related to working memory and planning. The findings support a link between maternal weight and child neurodevelopment. Continued research that help identify biological mechanisms are needed.

【 授权许可】

Unknown