TLR4 +896A>G (Asp299Gly) polymorphism is not associated with asthma: a update meta-analysis

International Journal of Clinical and Experimental Medicine

Yuelong Jin¹  Xiaohua Ren¹  Lianping He¹  Jie Li¹  Weiwei Chang¹  Yingshui Yao¹  Chaopin Li¹ 

关键词: Toll-Like Receptor 4;    single nucleotide polymorphism;    asthma;    polymorphism;    meta-analysis;   

DOI  :  

学科分类：医学（综合）

来源: e-Century Publishing Corporation

【 摘 要 】

Some research reported that polymorphisms in the toll-Like receptor 4 may have influence on asthma risk. Here, we sought to estimate the effects of Toll-Like Receptor 4 (Asp299Gly) genes on asthma risk. Databases including PubMed and Chinese National Knowledge Infrastructure (CNKI) databases were searched to find relevant studies. The odds ratio (OR) with corresponding 95% confidence intervals (CIs) was performed. A total of 12 case-control studies were finally identified. This meta-analysis indicated that no significant association was found between TLR4 (Asp299Gly) genes and asthma risk (OR = 0.91, 95% CI = 0.71-1.12). In conclusion, our findings suggest that TLR4 +896A>G (Asp299Gly) polymorphism may not contribute to the risk of asthma.

【 授权许可】

Unknown