COVID-19 and Skin Manifestations: An Overview of Case Reports/Case Series and Meta-Analysis of Prevalence Studies

Frontiers in Medicine

article

Fatemeh Sameni¹  Bahareh Hajikhani²  Somayeh Yaslianifard³  Mehdi Goudarzi²  Parviz Owlia⁴  Mohammad Javad Nasiri²  Shervin Shokouhi⁵  Mahmood Bakhtiyari⁷  Masoud Dadashi³ 

[1] Department of Microbiology, Faculty of Medicine, Shahed University;Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences;Department of Microbiology, School of Medicine, Alborz University of Medical Sciences;Molecular Microbiology Research Center, Shahed University;Infectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medical Sciences;Department of Infectious Diseases and Tropical Medicine, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences;Non-communicable Diseases Research Center, Alborz University of Medical Sciences;Department of Community Medicine, Alborz University of Medical Sciences

关键词: coronavirus;    2019-nCoV;    COVID-19;    skin manifestations;    meta-analysis;   

DOI  :  10.3389/fmed.2020.573188

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Background and Aim: Since the onset of the 2019-nCoV disease (COVID-19), many skin manifestations have been reported in COVID-19 patients. This study aims to provide a systematic review and meta-analysis of various skin manifestations among patients with COVID-19 through case reports/case series and prevalence studies. Methods: A systematic literature search strategy was conducted by reviewing original research articles published in Medline, Web of Science, and Embase databases in 2020. Statistical analysis was performed using STATA software, version 14.0 (Stata Corporation, College Station, Texas, USA) to report the global prevalence of skin manifestations among patients with COVID-19. Results: Forty-three studies (35 articles were case reports/case series, and 8 articles were prevalence studies) were included in our study. A meta-analysis of prevalence studies showed that skin manifestations among patients with COVID-19 were reported in four countries (China, Thailand, France, and Italy), with an overall prevalence of 1.0% [(95% CI) 0.1–1.9] among 2,621 patients. Evaluation of the results of the case reports/case series revealed that, out of 54 patients with COVID-19, 48 patients (88.8%) showed skin manifestations. Erythematous rash (59.1%) and urticaria (14.8%) were the most common skin manifestation reported in studied patients. Conclusion: Infection with 2019-nCoV may lead to skin manifestations with various clinical symptoms. These clinical features combined with clinical symptoms of COVID-19 may aid in the timely diagnosis of patients with COVID-19.

【 授权许可】

CC BY