Frontiers in Medicine | |
Skin Manifestations in COVID-19 Patients: Are They Indicators for Disease Severity? A Systematic Review | |
article | |
Parnian Jamshidi1  Bahareh Hajikhani2  Mehdi Mirsaeidi3  Hassan Vahidnezhad4  Masoud Dadashi5  Mohammad Javad Nasiri2  | |
[1] Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences;Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences;Division of Pulmonary and Critical Care, University of Miami, United States;Department of Dermatology and Cutaneous Biology, Sidney Kimmel Medical College, Thomas Jefferson University, United States;Department of Microbiology, School of Medicine, Alborz University of Medical Sciences | |
关键词: COVID-19; coronavirus; COVID-19; skin manifestations; skin; pathology; systematic literature search; disease severity; mortality; prognosis; | |
DOI : 10.3389/fmed.2021.634208 | |
学科分类:社会科学、人文和艺术(综合) | |
来源: Frontiers | |
【 摘 要 】
Introduction: Until now, there are several reports on cutaneous manifestations in COVID-19 patients. However, the link between skin manifestations and the severity of the disease remains debatable. We conducted a systematic review to evaluate the temporal relationship between different types of skin lesions and the severity of COVID-19. Methods: A systematic search was conducted for relevant studies published between January and July 2020 using Pubmed/Medline, Embase, and Web of knowledge. The following keywords were used: “SARS-CoV-2” or “COVID-19” or “new coronavirus” or “Wuhan Coronavirus” or “coronavirus disease 2019” and “skin disease” or “skin manifestation” or “cutaneous manifestation.” Results: Out of 381 articles, 47 meet the inclusion criteria and a total of 1,847 patients with confirmed COVID-19 were examined. The overall frequency of cutaneous manifestations in COVID-19 patients was 5.95%. The maculopapular rash was the main reported skin involvement (37.3%) commonly occurred in middle-aged females with intermediate severity of the disease. Forty-eight percentage of the patients had a mild, 32% a moderate, and 20% a severe COVID-19 disease. The mild disease was mainly correlated with chilblain-like and urticaria-like lesions and patients with vascular lesions experienced a more severe disease. Seventy-two percentage of patients with chilblain-like lesions improved without any medication. The overall mortality rate was 4.5%. Patients with vascular lesions had the highest mortality rate (18.2%) and patients with urticaria-like lesions had the lowest mortality rate (2.2%). Conclusion: The mere occurrence of skin manifestations in COVID-19 patients is not an indicator for the disease severity, and it highly depends on the type of skin lesions. Chilblain-like and vascular lesions are the ends of a spectrum in which from chilblain-like to vascular lesions, the severity of the disease increases, and the patient's prognosis worsens. Those with vascular lesions should also be considered as high-priority patients for further medical care.
【 授权许可】
CC BY
【 预 览 】
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RO202108180001494ZK.pdf | 591KB | download |