Body Localization of ACE-2: On the Trail of the Keyhole of SARS-CoV-2

Frontiers in Medicine

article

Francesca Salamanna¹  Melania Maglio¹  Maria Paola Landini¹  Milena Fini¹ 

[1] Surgical Sciences and Technologies, Istituto di Ricovero e Cura a Carattere Scientifico Istituto Ortopedico Rizzoli

关键词: SARS-CoV-2;    COVID-19;    ACE2;    ACE2 receptor;    body localization;   

DOI  :  10.3389/fmed.2020.594495

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

The explosion of the new coronavirus (SARS-CoV-2) pandemic has brought the role of the angiotensin converting enzyme 2 (ACE2) back into the scientific limelight. Since SARS-CoV-2 must bind the ACE2 for entering the host cells in humans, its expression and body localization are critical to track the potential target organ of this infection and to outline disease progression and clinical outcomes. Here, we mapped the physiological body distribution, expression, and activities of ACE2 and discussed its potential correlations and mutal interactions with the disparate symptoms present in SARS-CoV-2 patients at the level of different organs. We highlighted that despite during SARS-CoV-2 infection ACE2-expressing organs may become direct targets, leading to severe pathological manifestations, and subsequent multiple organ failures, the exact mechanism and the potential interactions through which ACE2 acts in these organs is still heavily debated. Further scientific efforts, also considering a personalized approach aimed to consider specific patient differences in the mutual interactions ACE2-SARS-CoV-2 and the long-term health effects associated with COVID-19 are currently mandatory.

【 授权许可】

CC BY