Prioritized Research for the Prevention, Treatment, and Reversal of Chronic Disease: Recommendations From the Lifestyle Medicine Research Summit

Frontiers in Medicine

article

Yoram Vodovotz¹  Gwendolyn Sowa²  Paul Verschure³  Kim Williams⁴  Eduardo Sanchez¹  Wayne Dysinger¹  Victoria Maizes⁵  Caesar Junker⁶  Edward Phillips⁷  David Katz⁸  Stacey Drant⁹  Neal Barnard^1,10  Richard J. Jackson^1,11  Leonardo Trasande^1,12  Steven Woolf^1,13  Marcel Salive^1,14  Jeannette South-Paul^1,15  Sarah L. States¹  Loren Roth^1,16  Gary Fraser^1,17  Ron Stout^1,18  Michael D. Parkinson^1,19  Frank B. Hu^2,20  John Jakicic^2,21  Liana Lianov^2,22  David Loveland^2,23  Daniel Buysse^1,16  Eva Szigethy^1,16  Toren Finkel^2,24 

[1] Department of Surgery, University of Pittsburgh, United States;Department of Physical Medicine and Rehabilitation, University of Pittsburgh, United States;Institute for Bioengineering of Catalunya, Barcelona Institute of Science and Technology, Catalan Institute of Advanced Studies;Department of Internal Medicine, Rush University Medical Center, United States;Department of Internal Medicine, University of Arizona, United States;United States Air Force, United States;Department of Physical Medicine and Rehabilitation, Veterans Administration Boston Healthcare System, United States;True Health Initiative, United States;Department of Pediatrics, University of Pittsburgh, United States;Department of Medicine, George Washington University School of Medicine, United States;Department of Environmental Health Sciences, University of California, United States;Department of Pediatrics and Environmental Medicine, New York University, United States;Department of Family Medicine and Population Health, Virginia Commonwealth University, United States;Division of Geriatrics and Clinical Gerontology, National Institute on Aging, United States;Department of Family Medicine, University of Pittsburgh, United States;Department of Psychiatry, University of Pittsburgh, United States;Department of Medicine, Preventive Medicine and Public Health, Loma Linda University, United States;Ardmore Institute of Health, United States;University of Pittsburgh Medical Center Health Plan/WorkPartners, United States;Department of Nutrition, Harvard T.H. Chan School of Public Health, United States;School of Education, University of Pittsburgh, United States;American College of Lifestyle Medicine, United States;Community Care, United States;Department of Medicine, University of Pittsburgh, United States

关键词: lifestyle medicine;    chronic disease;    inflammation;    epigenetics;    research methodologies;    in silico modeling;    nutrition;    physical activity;   

DOI  :  10.3389/fmed.2020.585744

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Declining life expectancy and increasing all-cause mortality in the United States have been associated with unhealthy behaviors, socioecological factors, and preventable disease. A growing body of basic science, clinical research, and population health evidence points to the benefits of healthy behaviors, environments and policies to maintain health and prevent, treat, and reverse the root causes of common chronic diseases. Similarly, innovations in research methodologies, standards of evidence, emergence of unique study cohorts, and breakthroughs in data analytics and modeling create new possibilities for producing biomedical knowledge and clinical translation. To understand these advances and inform future directions research, The Lifestyle Medicine Research Summit was convened at the University of Pittsburgh on December 4–5, 2019. The Summit's goal was to review current status and define research priorities in the six core areas of lifestyle medicine: plant-predominant nutrition, physical activity, sleep, stress, addictive behaviors, and positive psychology/social connection. Forty invited subject matter experts (1) reviewed existing knowledge and gaps relating lifestyle behaviors to common chronic diseases, such as cardiovascular disease, diabetes, many cancers, inflammatory- and immune-related disorders and other conditions; and (2) discussed the potential for applying cutting-edge molecular, cellular, epigenetic and emerging science knowledge and computational methodologies, research designs, and study cohorts to accelerate clinical applications across all six domains of lifestyle medicine. Notably, federal health agencies, such as the Department of Defense and Veterans Administration have begun to adopt “whole-person health and performance” models that address these lifestyle and environmental root causes of chronic disease and associated morbidity, mortality, and cost. Recommendations strongly support leveraging emerging research methodologies, systems biology, and computational modeling in order to accelerate effective clinical and population solutions to improve health and reduce societal costs. New and alternative hierarchies of evidence are also be needed in order to assess the quality of evidence and develop evidence-based guidelines on lifestyle medicine. Children and underserved populations were identified as prioritized groups to study. The COVID-19 pandemic, which disproportionately impacts people with chronic diseases that are amenable to effective lifestyle medicine interventions, makes the Summit's findings and recommendations for future research particularly timely and relevant.

【 授权许可】

CC BY