Understanding the Interplay Between Health Disparities and Epigenomics

Frontiers in Genetics

Noah C. Peeri¹  Viviana J. Mancilla²  Talisa Silzer²  Jamboor K. Vishwanatha⁴  Martha Felini⁴  Nicole Phillips⁴  Srikantha Thyagarajan⁴  Harlan P. Jones⁴  Riyaz Basha⁴  Meng-Hua Tao⁴ 

[1] Department of Biostatistics and Epidemiology, School of Public Health, University of North Texas Health Science Center, Fort Worth, TX, United States;Department of Microbiology, Immunology and Genetics, Graduate School of Biomedical Sciences, University of North Texas Health Science Center, Fort Worth, TX, United States;Department of Pediatrics, Texas College of Osteopathic Medicine, University of North Texas Health Science Center, Fort Worth, TX, United States;Texas Center for Health Disparities, University of North Texas Health Science Center, Fort Worth, TX, United States;

关键词: epigenetics;    cancer;    health disparities;    chronic disease;    social determinants of health;   

DOI  :  10.3389/fgene.2020.00903

来源: DOAJ

【 摘 要 】

Social epigenomics has emerged as an integrative field of research focused on identification of socio-environmental factors, their influence on human biology through epigenomic modifications, and how they contribute to current health disparities. Several health disparities studies have been published using genetic-based approaches; however, increasing accessibility and affordability of molecular technologies have allowed for an in-depth investigation of the influence of external factors on epigenetic modifications (e.g., DNA methylation, micro-RNA expression). Currently, research is focused on epigenetic changes in response to environment, as well as targeted epigenetic therapies and environmental/social strategies for potentially minimizing certain health disparities. Here, we will review recent findings in this field pertaining to conditions and diseases over life span encompassing prenatal to adult stages.

【 授权许可】

Unknown