Epigenetic Signaling and RNA Regulation in Cardiovascular Diseases

International Journal of Molecular Sciences

Tiziana Bachetti¹  Antonella Farsetti²  Carlo Gaetano³  Alessia Mongelli³  Sandra Atlante³  Fabio Martelli⁴ 

[1] Direzione Scientifica, Istituti Clinici Scientifici Maugeri IRCCS, Via Maugeri 4, 27100 Pavia, Italy;Institute for Systems Analysis and Computer Science “A. Ruberti” (IASI), National Research Council (CNR), 00185 Rome, Italy;Laboratorio di Epigenetica, Istituti Clinici Scientifici Maugeri IRCCS, Via Maugeri 4, 27100 Pavia, Italy;Molecular Cardiology Laboratory, Policlinico San Donato IRCCS, San Donato Milanese, 20097 Milan, Italy;

关键词: epigenetics;    nucleic acids;    rna;    dna;    cardiovascular disease;    chronic disease;    aging;    metabolism;   

DOI  :  10.3390/ijms21020509

来源: DOAJ

【 摘 要 】

RNA epigenetics is perhaps the most recent field of interest for translational epigeneticists. RNA modifications create such an extensive network of epigenetically driven combinations whose role in physiology and pathophysiology is still far from being elucidated. Not surprisingly, some of the players determining changes in RNA structure are in common with those involved in DNA and chromatin structure regulation, while other molecules seem very specific to RNA. It is envisaged, then, that new small molecules, acting selectively on RNA epigenetic changes, will be reported soon, opening new therapeutic interventions based on the correction of the RNA epigenetic landscape. In this review, we shall summarize some aspects of RNA epigenetics limited to those in which the potential clinical translatability to cardiovascular disease is emerging.

【 授权许可】

Unknown