Design, Bioanalytical, and Biomedical Applications of Aptamer-Based Hydrogels

Frontiers in Medicine

article

Ya Di¹  Ping Wang²  Chunyan Li²  Shufeng Xu¹  Qi Tian¹  Tong Wu¹  Yaling Tian¹  Liming Gao¹ 

[1]Department of Respiratory Medicine, The First Hospital of Qinhuangdao

[2]Department of Respiratory Medicine, Chinese People's Liberation Army General Hospital

关键词: aptamer-based hydrogels;    aptamer;    hydrogels;    bioanalysis;    biomedicine;   

DOI  :  10.3389/fmed.2020.00456

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Aptamers are special types of single-stranded DNA generated by a process called systematic evolution of ligands by exponential enrichment (SELEX). Due to significant advances in the chemical synthesis and biotechnological production, aptamers have gained considerable attention as versatile building blocks for the next generation of soft materials. Hydrogels are high water-retainable materials with a three-dimensional (3D) polymeric network. Aptamers, as a vital element, have greatly expanded the applications of hydrogels. Due to their biocompatibility, selective binding, and molecular recognition, aptamer-based hydrogels can be utilized for bioanalytical and biomedical applications. In this review, we focus on the latest strategies of aptamer-based hydrogels in bioanalytical and biomedical applications. We begin this review with an overview of the underlying design principles for the construction of aptamer-based hydrogels. Next, we will discuss some bioanalytical and biomedical applications of aptamer-based hydrogel including biosensing, target capture and release, logic devices, gene and cancer therapy. Finally, the recent progress of aptamer-based hydrogels is discussed, along with challenges and future perspectives.

【 授权许可】

CC BY