COVID-19 and the Kidneys: An Update

Frontiers in Medicine

article

Claudia Benedetti¹  Meryl Waldman²  Gianluigi Zaza³  Leonardo V. Riella⁴  Paolo Cravedi¹ 

[1] Department of Medicine, Icahn School of Medicine at Mount Sinai, United States;Kidney Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, United States;Renal Unit, Department of Medicine, University Hospital of Verona;Renal Division, Harvard Medical School, Massachusetts General Hospital, United States

关键词: acute kidney injury;    AKI;    COVID-19;    dialysis;    transplant;   

DOI  :  10.3389/fmed.2020.00423

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

The new coronavirus disease 2019 (COVID-19) has become a world health emergency. The disease predominantly effects individuals between 30 and 79 years of age with 81% of cases being classified as mild. Despite the majority of the general population displaying symptoms similar to the common cold, COVID-19 has also induced alveolar damage resulting in progressive respiratory failure with fatalities noted in 6.4% of cases. Direct viral injury, uncontrolled inflammation, activation of coagulation, and complement cascades are thought to participate in disease pathogenesis. Patients with COVID-19 have displayed kidney damage through acute kidney injury, mild proteinuria, hematuria, or slight elevation in creatinine possibly as consequence of kidney tropism of the virus and multiorgan failure. The impact of COVID-19 on patients with pre-existing kidney impairment, including those with chronic kidney disease, kidney transplant recipients, and individuals on hemodialysis (HD) has not yet been clearly established. No specific treatments for COVID-19 have been found yet. Research has revealed several agents that may have potential efficacy against COVID-19, and many of these molecules have demonstrated preliminary efficacy against COVID-19 and are currently being tested in clinical trials.

【 授权许可】

CC BY