Comparison of Clinical Features in HLA-B27 Positive and Negative Patients With Axial Spondyloarthritis: Results From a Cohort of 4,131 Patients

Frontiers in Medicine

article

Shangzhu Zhang¹  Lijun Wu²  Cheng Zhao³  Xinwang Duan⁴  Qin Li⁵  Jing Zhu⁶  Wenqiang Fan⁷  Yanhong Wang⁸  Linyi Peng¹  Jinmei Su¹  Xiaofeng Zeng¹  Mengtao Li¹  Zhenbiao Wu⁹  Jian Xu^1,10  Min Yang^1,11 

[1] Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Ministry of Science and Technology, Department of Rheumatology, National Clinical Research Center for Dermatologic and Immunologic Diseases, Peking Union Medical College, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences;Department of Rheumatology, The People's Hospital of Xinjiang Uygur Autonomous Region;Department of Rheumatology, Guangxi Medical University First Affiliated Hospital;Department of Rheumatology, Nanchang University Second Affiliated Hospital;Department of Rheumatology, First People's Hospital of Yunnan;Department of Rheumatology, Sichuan Provincial People's Hospital;Department of Rheumatology, Xinxiang Central Hospital;Department of Epidemiology and Bio-Statistics (YW), Peking Union Medical College, Institute of Basic Medical Sciences, China Academy of Medical Sciences;Department of Rheumatology, Xijing Hospital affiliated to the Fourth Military Medical University;Department of Rheumatology, Kunming Medical University First Affiliated Hospital;Department of Rheumatology, Nanfang Hospital Affiliated to Southern Medical University

关键词: HLA-B27;    family history;    uveitis;    psoriasis;    axial spondyloarthritis (axSpA);   

DOI  :  10.3389/fmed.2020.609562

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Objective: The aim of our study was to assess the influence of the HLA-B27 status on axial spondyloarthritis (axSpA) in the largest cohort in China. Methods: An observational, cross-sectional, and analytic study of axSpA patients from the China axSpA database was performed. Demographic and clinical data were compared in terms of the HLA-B27 status. Univariate and multivariate analyses were performed to identify variables related to HLA-B27 presence. Results: We enrolled 4,131 patients in this study; of those, 36,95 (89.4%) were HLA-B27 positive. In the multivariate analysis, male gender ( p 36 months ( p < 0.001) and psoriasis ( p < 0.001) were independently related to HLA-B27 absence. Conclusion: In Chinese axial SpA patients, presence of HLA-B27 is associated with the male sex, younger age, longer disease duration, greater family aggregation, and higher frequency of uveitis; absence of HLA-B27 is associated with longer diagnosis delay time and higher frequency of psoriasis.

【 授权许可】

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