Characteristics of Renal Function in Patients Diagnosed With COVID-19: An Observational Study

Frontiers in Medicine

article

Xu-wei Hong¹  Ling-jie Wu²  Liang-yu Wang³  Qi-chuan Zhang⁴  Su-wu Wu⁵  Ze-qun Pan⁶  Hao Lin⁶  Yu-hua Zhou⁷  Yong-hai Zhang¹  Ze-pai Chi¹  Guo-yuan Liu¹  Hong Huang¹  Shun-qi Guo⁸  Jing-ru Fan⁸  Xian-wei Lin⁹  Liao-zhun Qu^1,10  Rui-lie Chen² 

[1] Department of Urology, Shantou Central Hospital;Department of Infectious Diseases, Shantou Central Hospital;Department of Ultrasonic Medicine, Shantou Central Hospital;Department of Respiratory Medicine, Shantou Central Hospital;Department of Intensive Care Unit, Shantou Central Hospital;Medical Department, Shantou Central Hospital;Nursing Department, Shantou Central Hospital;Department of Emergency, Shantou Central Hospital;Department of Laboratory Medicine, Shantou Central Hospital;Department of Nephrology, Shantou Central Hospital

关键词: 2019-nCoV;    COVID-19;    renal function;    urinary microprotein;    multiple indicators;   

DOI  :  10.3389/fmed.2020.00409

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Objective: The aim of the study was to analyze the characteristics of renal function in patients diagnosed with COVID-19. Methods: In this retrospective, single-center study, we included all confirmed cases of COVID-19 in a tertiary hospital in Guangdong, China from January 20, 2020 to March 20, 2020. Blood and urine laboratory findings related to renal function were summarized, and the estimated glomerular filtration rate (eGFR) and endogenous creatinine clearance (Ccr) were also calculated to assess the renal function. Results: A total of 12 admitted hospital patients were diagnosed with COVID-19, included 3 severe cases, and 9 common cases. Serum creatinine (Scr) was not abnormally elevated in all of the patients, and blood urea nitrogen (BUN) was abnormally elevated in only 25.0% of the patients. However, compared with the recovery period, the patient's Scr and BUN increased significantly in peak of disease (p-scr = 0.002 & p-bun < 0.001). By observing the fluctuations in Scr and BUN from admission to recovery, it was found that the peak of Scr and BUN appeared within the first 14 day of the course of the disease. Urinary microprotein detection indicated that the abnormally elevated rates of urine microalbumin (UMA), α1-microglobulin (A1M), urine immunoglobulin-G (IGU), and urine transferring (TRU) standardized by urinary creatinine in peak of disease were 41.7, 41.7, 50.0, and 16.7%, respectively. The abnormal rates of the calculated eGFR and Ccr were 66.7 and 41.7%. Conclusion: Scr and BUN were generally increased during the course of COVID-19. Detection of urinary microproteins and application of multiple indicators assessment could be helpful for discovering abnormal renal function in patients with COVID-19. However, the evidence is limited due to the small sample size and observational nature. Additional studies, especially large prospective cohort studies, are required to confirm these findings.

【 授权许可】

CC BY