First Report on the Latvian SARS-CoV-2 Isolate Genetic Diversity

Frontiers in Medicine

Marta Priedite¹  Anastasija Caica¹  Mikus Gavars²  Dmitry Perminov³  Uga Dumpis⁴  Elina Dimina⁵  Lauma Freimane⁶  Liga Birzniece⁶  Ivars Silamikelis⁶  Davids Fridmanis⁶  Nikita Zrelovs⁶  Laila Silamikele⁶  Vita Rovite⁶  Janis Klovins⁶  Monta Ustinova⁶  Janis Pjalkovskis⁶  Kaspars Megnis⁶  Laura Ansone⁶  Baiba Vilne⁷  Oksana Savicka⁸  Jelena Storozenko⁸ 

[1] Centrala Laboratorija, Ltd, Riga, Latvia;E. Gulbja Laboratorija, Ltd, Riga, Latvia;E. Gulbja Laboratorija, Ltd, Riga, Latvia;Faculty of Biology, University of Latvia, Riga, Latvia;Faculty of Medicine, University of Latvia, Riga, Latvia;Pauls Stradins Clinical University Hospital, Riga, Latvia;Infectious Diseases Surveillance and Immunization Division, Infectious Diseases Risk Analysis and Prevention Department, The Centre for Disease Prevention and Control (CDPC) of Latvia, Riga, Latvia;Latvian Biomedical Research and Study Centre, Riga, Latvia;Riga Stradins University, Riga, Latvia;Riga Stradins University, Riga, Latvia;Laboratory Service, Latvian Centre of Infectious Diseases Laboratory, National Microbiology Reference Laboratory, Molecular Biology and Virology Department, Riga East University Hospital, Riga, Latvia;

关键词: Latvia;    COVID-19;    next-generation sequencing;    genetic diversity;    2019-nCoV;    HCoV-19;    SARS-CoV-2;   

DOI  :  10.3389/fmed.2021.626000

来源: Frontiers

【 摘 要 】

Remaining a major healthcare concern with nearly 29 million confirmed cases worldwide at the time of writing, novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has caused more than 920 thousand deaths since its outbreak in China, December 2019. First case of a person testing positive for SARS-CoV-2 infection within the territory of the Republic of Latvia was registered on 2nd of March 2020, 9 days prior to the pandemic declaration by WHO. Since then, more than 277,000 tests were carried out confirming a total of 1,464 cases of coronavirus disease 2019 (COVID-19) in the country as of 12th of September 2020. Rapidly reacting to the spread of the infection, an ongoing sequencing campaign was started mid-March in collaboration with the local testing laboratories, with an ultimate goal in sequencing as much local viral isolates as possible, resulting in first full-length SARS-CoV-2 isolate genome sequences from the Baltics region being made publicly available in early April. With 133 viral isolates representing ~9.1% of the total COVID-19 cases during the “first coronavirus wave” in the country (early March, 2020—mid-September, 2020) being completely sequenced as of today, here, we provide a first report on the genetic diversity of Latvian SARS-CoV-2 isolates.

【 授权许可】

CC BY