First Report on the Latvian SARS-CoV-2 Isolate Genetic Diversity

Frontiers in Medicine

article

Nikita Zrelovs¹  Janis Pjalkovskis¹  Davids Fridmanis¹  Baiba Vilne²  Marta Priedite³  Anastasija Caica³  Mikus Gavars⁴  Dmitry Perminov⁵  Jelena Storozenko²  Oksana Savicka²  Elina Dimina⁷  Monta Ustinova¹  Uga Dumpis⁸  Janis Klovins¹  Ivars Silamikelis¹  Liga Birzniece¹  Kaspars Megnis¹  Vita Rovite¹  Lauma Freimane¹  Laila Silamikele¹  Laura Ansone¹ 

[1] Latvian Biomedical Research and Study Centre;Riga Stradins University;Centrala Laboratorija, Ltd;E. Gulbja Laboratorija, Ltd;Faculty of Biology, University of Latvia;Laboratory Service, Latvian Centre of Infectious Diseases Laboratory, National Microbiology Reference Laboratory, Molecular Biology and Virology Department, Riga East University Hospital;Infectious Diseases Surveillance and Immunization Division, Infectious Diseases Risk Analysis and Prevention Department, The Centre for Disease Prevention and Control (CDPC) of Latvia;Faculty of Medicine, University of Latvia;Pauls Stradins Clinical University Hospital

关键词: Latvia;    COVID-19;    next-generation sequencing;    genetic diversity;    2019-nCoV;    HCoV-19;    SARS-CoV-2;   

DOI  :  10.3389/fmed.2021.626000

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Remaining a major healthcare concern with nearly 29 million confirmed cases worldwide at the time of writing, novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has caused more than 920 thousand deaths since its outbreak in China, December 2019. First case of a person testing positive for SARS-CoV-2 infection within the territory of the Republic of Latvia was registered on 2nd of March 2020, 9 days prior to the pandemic declaration by WHO. Since then, more than 277,000 tests were carried out confirming a total of 1,464 cases of coronavirus disease 2019 (COVID-19) in the country as of 12th of September 2020. Rapidly reacting to the spread of the infection, an ongoing sequencing campaign was started mid-March in collaboration with the local testing laboratories, with an ultimate goal in sequencing as much local viral isolates as possible, resulting in first full-length SARS-CoV-2 isolate genome sequences from the Baltics region being made publicly available in early April. With 133 viral isolates representing ~9.1% of the total COVID-19 cases during the “first coronavirus wave” in the country (early March, 2020—mid-September, 2020) being completely sequenced as of today, here, we provide a first report on the genetic diversity of Latvian SARS-CoV-2 isolates.

【 授权许可】

CC BY