The Diagnostic Significance of Usual Biochemical Parameters in Coronavirus Disease 19 (COVID-19): Albumin to Globulin Ratio and CRP to Albumin Ratio

Frontiers in Medicine

article

Gavriela M. Feketea¹  Vasiliki Vlacha³ 

[1] Department of Hematology, “Iuliu Hatieganu” University of Medicine and Pharmacy;Department of Pediatrics, Pediatric Allergy Outpatient Clinic, Karamandaneio Children Hospital of Patras;Department of Early Years Learning and Care, University of Ioannina

关键词: albumin/globulin ratio (AGR);    CRP/albumin ratio;    COVID-19;    SARS-CoV-2;    kawasaki like disease;    ARSD;    ICU;    intensive care unit;   

DOI  :  10.3389/fmed.2020.566591

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

The clinical course of patients with COVID-19, and the progression to severe disease, are difficult to predict. There is a growing interest in identifying individuals who could be at greater risk for developing severe or critical COVID-19, acute respiratory distress syndrome (ARDS) in adults, Kawasaki-like disease in young individuals and children, and even death. Several laboratory parameters have been analyzed in conjunction with COVID-19. Specifically, significant elevation of C-reactive proteins, erythrocyte sedimentation rate, interleukin-6, and lactate dehydrogenase has been observed. On the other hand, the total white blood cell count and the eosinophilic and lymphocytic count have been decreased in COVID-19 patients. In a recent meta-analysis, increased CRP, lymphopenia, and increased LDH were significantly associated with the severity of the disease (1). The levels of certain laboratory values that proved to be elevated in cytokine storm (ferritin, procalcitonin, and troponin) may not be available at most hospital laboratories or are mainly used for research purposes (IL-6) (2, 3). On the other hand, CRP, albumin, and globulin are readily available, shortly after admittance, and are often part of an admission workup, in general hospitals and particularly in intensive care units (ICU).

【 授权许可】

CC BY