Association between angiotensinogen (AGT), angiotensin-converting enzyme (ACE) and angiotensin-II receptor 1 (AGTR1) polymorphisms and COVID-19 infection in the southeast of Iran: a preliminary case-control study

Translational Medicine Communications

Gholamreza Bahari¹  Tahereh Khalili²  Courtney Clark³  Saeid Ghavami³  Farhad Tabasi⁴  Mohammad Dehvari⁵  Mohsen Taheri⁶  Hamid Reza Kouhpayeh⁷  Mohammad Naderi⁷ 

[1] Children and Adolescent Health Research Center, Resistant Tuberculosis Institute, Zahedan University of Medical Sciences, Zahedan, Iran;Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran;Department of Human Anatomy and Cell Science, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada;Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran;Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran;Genetics of Non-communicable Disease Research Center, Zahedan University of Medical Sciences, Zahedan, Iran;Genetics of Non-communicable Disease Research Center, Zahedan University of Medical Sciences, Zahedan, Iran;Department of Genetic, School of Medicine, Zahedan University of Medical Sciences, 9816743463, Zahedan, Iran;Infectious Diseases and Tropical Medicine Research Center, Resistant Tuberculosis Institute, Zahedan University of Medical Sciences, Zahedan, Iran;

关键词: COVID-19;    SARS-CoV-2;    Angiotensin;    AGT;    ACE;    AGTR1;    Polymorphism;   

DOI  :  10.1186/s41231-021-00106-0

来源: Springer

【 摘 要 】

BackgroundThe COVID-19 pandemic remains an emerging public health crisis with serious adverse effects. The disease is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV--2) infection, targeting angiotensin-converting enzyme-2 (ACE2) receptor for cell entry. However, changes in the renin-angiotensin system (RAS) balance alter an individual’s susceptibility to COVID-19 infection. We aimed to evaluate the association between AGT rs699 C > T, ACE rs4646994 I/D, and AGTR1 rs5186 C > A variants and the risk of COVID-19 infection and the severity in a sample of the southeast Iranian population.MethodsA total of 504 subjects, including 258 COVID-19 positives, and 246 healthy controls, were recruited. Genotyping of the ACE gene rs4646994, and AGT rs699, and AGTR1 rs5186 polymorphisms was performed by polymerase chain reaction (PCR) and PCR-restriction fragment length polymorphism (PCR-RFLP), respectively.ResultsOur results showed that the II genotype of ACE rs4646994 and the I allele decreased the risk of COVID-19 infection. Moreover, we found that the TC genotype and C allele of AGT rs699 increased the risk of COVID-19 infection. The AGTR1 rs5186 was not associated with COVID-19 infection. Also, we did not find any association between these polymorphisms and the severity of the disease. However, we found a significantly higher age and prevalence of diabetes and hypertension in patients with severe disease than a non-severe disease.ConclusionsThese findings suggest that ACE rs4646994 and AGT rs699 polymorphisms increase the risk of COVID-19 infection in a southeast Iranian population.

【 授权许可】

CC BY