Efficacy of Electroacupuncture Therapy in Patients With Postherpetic Neuralgia: Study Protocol for a Multicentre, Randomized, Controlled, Assessor-Blinded Trial

Frontiers in Medicine

article

Hantong Hu¹  Yejing Shen²  Xinwei Li³  Hongfang Tian¹  XingLing Li¹  Yang Li¹  Yingying Cheng¹  Lei Wu¹  Dexiong Han¹ 

[1] Department of Acupuncture and Moxibustion, The Third Affiliated Hospital of Zhejiang Chinese Medical University;Department of Acupuncture and Moxibustion, Lishui Hospital of Traditional Chinese Medicine;Department of Acupuncture and Moxibustion, Tongde Hospital of Zhejiang Province

关键词: electroacupuncture;    postherpetic neuralgia;    pain;    randomized controlled trial;    protocol;   

DOI  :  10.3389/fmed.2021.624797

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Introduction: The efficacy of conventional treatments for treating postherpetic neuralgia (PHN) remains unsatisfactory. Thus, this multicentre, randomized controlled, assessor-blinded trial aims to investigate the efficacy and safety of electroacupuncture (EA) therapy in patients with PHN. Methods and Analysis: This multicentre randomized controlled trial will enroll 132 patients with PHN from 3 hospitals. All patients will be randomly assigned to either the EA combined with medication group or medication group through a computerized central randomization system in a 1:1 ratio. Outcome measures will be assessed before intervention, at 2, 4, 6 weeks after intervention and at the end of 8-week follow-up. Primary outcomes will be sensory thresholds and pain intensity. Secondary outcomes will include dosage of analgetic, quality of life, anxiety, and depression severity and sleep quality. All adverse effects will be assessed during the trial. Conclusions: This study will provide evidence to ascertain whether EA is effective and safe for treating PHN. Ethics and Dissemination: Ethics approval (No.ZSLL-KY-2017-025) has been obtained from the Ethics Committee of The Third Affiliated Hospital of Zhejiang Chinese Medical University. Informed consent will be signed prior to subject enrolment. The results will be submitted to international peer-reviewed journals and presented at international conferences. Trial Registration Number: The study protocol has been registered in the clinicaltrials registry with the identification code {"type":"clinical-trial","attrs":{"text":"NCT04594226","term_id":"NCT04594226"}} NCT04594226 .

【 授权许可】

CC BY