Early Life Stress, Physiology, and Genetics: A Review

Frontiers in Psychology

article

Nia Fogelman¹  Turhan Canli¹ 

[1] Department of Psychology, Stony Brook University, United States

关键词: early life stress;    sympathetic nervous system;    hypothalamic-pituitary-adrenal axis;    inflammation;    genetics;    epigenetics;   

DOI  :  10.3389/fpsyg.2019.01668

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Early life stress (ELS) is a widely studied concept due to both its prevalent nature and its (presumed) detrimental consequences. In this review, we discuss the relationship between ELS and its underlying physiology spanning the sympathetic nervous system, hypothalamic-pituitary-adrenal axis, and markers of inflammation related to immune function in both human and animal literature. We also consider the potential role of genetic and epigenetic factors on the ELS-health outcome relationship. We conclude with recommendations to overcome identified shortcomings in a field that seeks to address the health consequences of ELS.

【 授权许可】

CC BY