期刊论文详细信息
Biomedicines
Neuroinflammation in Post-Traumatic Stress Disorder
Sang-Won Park1  Ji-Young Lee1  Dong-Hun Lee1  Dong-Yong Hong1  Eun-Chae Lee1  Jae-Sang Oh1  Man-Ryul Lee2 
[1] Department of Neurosurgery, College of Medicine, Soonchunhyang University, Cheonan Hospital, Cheonan 31151, Korea;Soonchunhyang Institute of Medi-Bio Science (SIMS), Soon Chun Hyang University, Cheonan 31151, Korea;
关键词: animal models;    behavior test;    damage-associated molecular patterns;    hypothalamic-pituitary-adrenal axis;    inflammation;    kynurenine;   
DOI  :  10.3390/biomedicines10050953
来源: DOAJ
【 摘 要 】

Post-traumatic stress disorder (PTSD) is a well-known mental illness, which is caused by various stressors, including memories of past physical assaults and psychological pressure. It is diagnosed as a mental and behavioral disorder, but increasing evidence is linking it to the immune system and inflammatory response. Studies on the relationship between inflammation and PTSD revealed that patients with PTSD had increased levels of inflammatory cytokine biomarkers, such as interleukin-1, interleukin-6, tumor necrosis factor-α, nuclear factor-κB, and C-reactive protein, compared with healthy controls. In addition, animal model experiments imitating PTSD patients suggested the role of inflammation in the pathogenesis and pathophysiology of PTSD. In this review, we summarize the definition of PTSD and its association with increased inflammation, its mechanisms, and future predictable diseases and treatment possibilities. We also discuss anti-inflammatory treatments to address inflammation in PTSD.

【 授权许可】

Unknown   

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