Long-term survival of a dog with Alexander disease

The Journal of Veterinary Medical Science

article

Yui KOBATAKE¹  Nao NISHIMURA¹  Hiroki SAKAI¹  Syunsuke IWANA⁴  Osamu YAMATO⁵  Naohito NISHII¹  Hiroaki KAMISHINA¹ 

[1] Faculty of Applied Biological Sciences, Gifu University;The United Graduate School of Veterinary Sciences, Gifu University;Center for Highly Advanced Integration of Nano and Life Sciences, Gifu University;Kohnan Animal Hospital;Joint Faculty of Veterinary Medicine, Kagoshima University

关键词: Alexander disease;    astrocyte;    canine;    neurodegenerative disease;    Rosenthal fibers;   

DOI  :  10.1292/jvms.20-0133

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

A 1-year- and 11-month-old spayed female toy poodle had showed progressive ataxia and paresis in the hindlimbs since 11 months old. Magnetic resonance imaging revealed high signal intensity on T2-weighted and fluid-attenuated inversion recovery images at the thoracic and lumbar spinal cord. The dog’s neurological condition slowly deteriorated and flaccid tetraparesis was exhibited. At 4 years and 11 months old, the dog died of respiratory failure. On postmortem examination, eosinophilic corkscrew bundles (Rosenthal fibers) were observed mainly in the thoracic and lumbar spinal cord. Histological features were comparable to previously reported cases with Alexander disease. This is a first case report to describe the clinical course and long-term prognosis of a dog with Alexander disease.

【 授权许可】

Unknown