Cortical metabolic and structural differences in patients with chronic migraine. An exploratory 18FDG-PET and MRI study

The Journal of Headache and Pain

Marta Torres-Ferrus¹  Alicia Alpuente¹  Patricia Pozo-Rosich¹  Edoardo Caronna²  Adrià Vila-Balló²  Victor J Gallardo²  Carles Lorenzo-Bosquet³  Joan Castell-Conesa³  Gemma Cuberas-Borrós⁴  Deborah Pareto⁵  Alex Rovira⁵ 

[1] Headache and Craniofacial Pain Unit, Neurology Department, Vall d’Hebron University Hospital, Barcelona, Spain;Headache and Neurological Pain Research Group, Vall d’Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain;Headache and Neurological Pain Research Group, Vall d’Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain;Nuclear Medicine Department, Vall d’Hebron University Hospital, Barcelona, Spain;Research and Innovation Unit, Althaia Xarxa Assistencial Universitària de Manresa, Manresa, Spain;Nuclear Medicine Department, Vall d’Hebron University Hospital, Barcelona, Spain;Section of Neuroradiology, Department of Radiology, Vall d’Hebron University Hospital and Research Institute (VHIR), Barcelona, Spain;

关键词: Chronic migraine;    Neuroimaging;    Positron emission tomography;    Cortical thickness;    Metabolism;    Structural;   

DOI  :  10.1186/s10194-021-01289-5

来源: Springer

【 摘 要 】

BackgroundTo describe interictal brain structural and metabolic differences between patients with episodic migraine (EM), chronic migraine (CM) and healthy controls (HC).MethodsThis is an exploratory study including right-handed age-matched women with EM, CM and HC. On the same day, a sequential interictal scan was performed with 18FDG-PET and MRI. 3D T1-weighted images were segmented with FreeSurfer, normalized to a reference atlas and the mean values of metabolism, cortical thickness (CTh) and local gyrification index (IGI) were determined. Groups were compared using age-adjusted linear models, corrected for multiple comparisons. 18FDG-PET measurements between groups were also analysed adjusting by patient’s age, CTh and lGI. The variables independently associated with diagnosis were obtained using a logistic regression analysis.ResultsFifteen patients (8 EM, 7 CM) and 11 HC were included. Morphometric data showed an increased CTh in 6 frontal areas (L/R-Caudal Middle Frontal, L/R-Rostral Middle Frontal, L-Medial Orbitofrontal and L-Superior Frontal) in CM patients compared to HC without differences for IGI. The structural adjusted analysis in CM showed a statistically significantly hypometabolism in 9 frontal areas (L-Lateral Orbitofrontal, L/R-Medial Orbitofrontal, L-Frontal Superior, R-Frontal pole, R-Parts Triangularis, L/R-Paracentral and R-Precentral) and 7 temporal areas (L/R-Insula, L/R-Inferior temporal, L/R-Temporal pole and R-Banks superior temporal sulcus) compared to HC. EM patients presented intermediate metabolic values ​​between EM and HC (non-significant).ConclusionsCM patients showed frontotemporal hypometabolism and increased frontal cortical thickness when compared to HC that may explain some cognitive and behavioural pain-processing and sensory integration alterations in CM patients. Combined information from sequential or simultaneous PET and MRI could optimize the study of complex functional neurological disorders such as migraine.

【 授权许可】

CC BY