Increased power by harmonizing structural MRI site differences with the ComBat batch adjustment method in ENIGMA

NeuroImage

Thomas Weickert¹  Cynthia S. Weickert²  Eduard Vieta³  David Tomecek³  Irina Lebedeva³  Igor Nenadić⁴  Theodore D. Satterthwaite⁴  Godfrey Pearlson⁵  Yann Quidé⁶  Henk Temmingh⁷  David Glahn⁸  Stanley Catts⁹  Gavin Cooper⁹  Shuping Tan⁹  Fengmei Fan⁹  Peter Kochunov^1,10  Stefan Kaiser^1,11  Rhoshel Lenroot^1,12  Matthias Kirschner^1,13  Sara Llufriu^1,14  Anthony James^1,15  Julian Pineda-Zapata^1,16  Kun Yang^1,17  Russell Shinohara^1,18  Vasily Kaleda^1,19  Akira Sawa^1,19  Antonin Skoch^1,19  Dan J. Stein^1,19  Geor Bakker^1,19  Anton Albajes-Eizagirre^2,20  Gianfranco Spalletta^2,20  Jingxu Chen^2,21  Paul Rasser^2,21  Zhiren Wang^2,21  Raquel Gur^2,21  Wenhao Jiang^2,22  Ulrich Schall^2,23  Rodney Scott^2,23  Christos Pantelis^2,23  Stefan du Plessis^2,23  Janice M. Fullerton^2,23  Annabella Di Giorgio^2,23  Christian Knöchel^2,24  Vanessa Cropley^2,25  Michael Stäblein^2,26  Ruben Gur^2,27  Hong Xiang^2,27  Fleur Howells^2,28  Adrian Preda^2,29  Edith Pomarol-Clotet^3,30  Jason Bruggemann^3,31  Je-Yeon Yun^3,32  Jessica Turner^3,33  Covadonga Díaz-Caneja^3,34  Melissa J. Green^3,35  Hua Guo^3,35  Patricia Michie^3,35  Andrea Weideman^3,35  Fude Yang^3,35  Therese van Amelsvoort^3,35  Paul Tooney^3,35  Yoichiro Takayanagi^3,35  Carlos López-Jaramillo^3,36  Dana Nguyen^3,37  Margaret King^3,38  Yunlong Tan^3,39  Kang Sim^3,39  Theo van Erp^4,40  Elisabeth Solana^4,41  Elliot Hong^4,42  Vaughan Carr^4,42  Axel Krug^4,42  Dominik Grotegerd^4,43  Clara Alloza^4,43  Aurora Bonvino^4,44  Peter McKenna^4,44  Lydia Fortea^4,45  Eloy Martinez-Heras^4,45  Ana Díaz-Zuluaga^4,45  Federica Piras^4,46  Erick J. Canales-Rodríguez^4,47  Anne Uhlmann^4,48  Alexander Tomyshev^4,49  Joaquim Radua^4,49  Cyril Hoschl^4,49  Nicola G. Cascella^5,50  Stefan Ehrlich^5,50  Vince Calhoun^5,50  Murray J. Cairns^5,51  Jun Soo Kwon^5,52  Viola Oertel^5,52  Nerisa Banaj^5,53  Tilo Kircher^5,54  Celso Arango^5,55  Alessandro Bertolino^5,56  Salvador Sarro^5,57  Daniel Wolf^5,58  Bryan Mowry^5,58  Stefan Borgwardt^5,58  Frans Henskens^5,58  Marc Seal^5,58  Carmel Loughland^5,58  Paul Thompson^5,59  Raymond Salvador^6,60  Francesca Assogna^6,61  Udo Dannlowski^6,62  Tim Hahn^6,62  Fabrizio Piras^6,62  Aleix Solanes^6,62  Neda Jahanshad^6,63  Joost Janssen^6,64 

[1] Barcelona Bipolar Disorders Program, Institute of Neurosciences, Hospital Clinic de Barcelona, Barcelona, Spain;Bipolar and depressive disorders, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain;CIBERSAM, Madrid, Spain;Center for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, PA, USA;Cognitive Sciences, College of Natural Sciences, Seoul National University, Seoul, Republic of Korea;Corresponding author. Imaging of Mood- and Anxiety-Related Disorders (IMARD) group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.;Department of Basic Medical Science, Neuroscience and Sense Organs, University of Bari ‘Aldo Moro’, Bari, Italy;;Department of Brain &Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, Madrid, Spain;Department of Clinical Neuroscience, Stockholm Health Care Services, Stockholm County Council, Karolinska Institutet, Stockholm, Sweden;Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA;;Department of Neuroscience &Department of Psychiatry and Forensic Medicine, School of Medicine, Autonomous University of Barcelona, Barcelona, Spain;Department of Psychiatry and Psychotherapy, University Lübeck, Germany;Department of Radiology, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland;Departments of Psychiatry, Neuroscience, and Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD, USA;Division of Neuropsychiatry, Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA;Early Psychosis: Interventions and Clinical-detection (EPIC) Lab, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK;FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain;Hunter Medical Research Institute, Newcastle, NSW, Australia;Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain;Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore;Neuroscience Research Australia, Sydney, NSW, Australia;North Western Mental Health, Melbourne Health, Melbourne, VIC, Australia;Physiology, Upstate Medical University, Syracuse, Newyork, NY, USA;Queensland Centre for Mental Health Research, The University of Queensland, Brisbane, QLD, Australia;School of Medicine, Universidad Complutense, Madrid, Spain;School of Medicine, Universitat Internacional de Catalunya, Barcelona, Spain;Signal Processing Lab (LTS5), École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland;The University of Melbourne, Australia;University of Barcelona, Barcelona, Spain;University of New Mexico, Albuquerque, NM, USA;Yeongeon Student Support Center, Seoul National University College of Medicine, Seoul, Republic of Korea;Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore;CIBERSAM, Madrid, Spain;Department of Basic Medical Science, Neuroscience and Sense Organs, University of Bari ‘Aldo Moro’, Bari, Italy;Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA;Department of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, Toyama, Japan;Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany;Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea;Department of Psychiatry, University of Basel, Basel, Switzerland;Department of Psychiatry, University of Münster, Münster, Germany;Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA;Departments of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD, USA;Dept. of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University Frankfurt, Frankfurt, Germany;Georgia State University, Atlanta, GA, USA;Health Behaviour Research Group, School of Medicine and Public Health, University of Newcastle, Newcastle, NSW, Australia;IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy;Imaging of Mood- and Anxiety-Related Disorders (IMARD) Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain;Laboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy;Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD, USA;Melbourne Neuropsychiatry Centre, Dept. of Psychiatry, University of Melbourne, Melbourne, VIC, Australia;Murdoch Children's Research Institute, Melbourne, VIC, Australia;Penn Statistics in Imaging and Visualization Center, Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, PA, USA;Psychiatry Research Center, Beijing Huilongguan Hospital, Beijing, China;Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia;School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia;School of Psychiatry, University of New South Wales, Sydney, NSW, Australia;Seoul National University Hospital, Seoul, Republic of Korea;Technische Universität Dresden, Faculty of Medicine, Division of Psychological and Social Medicine, Dresden, Germany;Tri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State, Georgia Tech, Emory, Atlanta, GA, USA;University of Newcastle, Newcastle, NSW, Australia;University of Stellenbosch, Cape Town, Western Province, South Africa;West Region and Research Division, Institute of Mental Health, Singapore, Singapore;

关键词: Brain;    Cortical thickness;    Gray matter;    Mega-analysis;    Neuroimaging;    Schizophrenia;   

DOI  :  

来源: DOAJ

【 摘 要 】

A common limitation of neuroimaging studies is their small sample sizes. To overcome this hurdle, the Enhancing Neuro Imaging Genetics through Meta-Analysis (ENIGMA) Consortium combines neuroimaging data from many institutions worldwide. However, this introduces heterogeneity due to different scanning devices and sequences. ENIGMA projects commonly address this heterogeneity with random-effects meta-analysis or mixed-effects mega-analysis. Here we tested whether the batch adjustment method, ComBat, can further reduce site-related heterogeneity and thus increase statistical power. We conducted random-effects meta-analyses, mixed-effects mega-analyses and ComBat mega-analyses to compare cortical thickness, surface area and subcortical volumes between 2897 individuals with a diagnosis of schizophrenia and 3141 healthy controls from 33 sites. Specifically, we compared the imaging data between individuals with schizophrenia and healthy controls, covarying for age and sex. The use of ComBat substantially increased the statistical significance of the findings as compared to random-effects meta-analyses. The findings were more similar when comparing ComBat with mixed-effects mega-analysis, although ComBat still slightly increased the statistical significance. ComBat also showed increased statistical power when we repeated the analyses with fewer sites. Results were nearly identical when we applied the ComBat harmonization separately for cortical thickness, cortical surface area and subcortical volumes. Therefore, we recommend applying the ComBat function to attenuate potential effects of site in ENIGMA projects and other multi-site structural imaging work. We provide easy-to-use functions in R that work even if imaging data are partially missing in some brain regions, and they can be trained with one data set and then applied to another (a requirement for some analyses such as machine learning).

【 授权许可】

Unknown