Broadening the biocompatibility of gold nanorods from rat to Macaca fascicularis: advancing clinical potential

Journal of Nanobiotechnology

Jingang Xiao¹  Shuanglin Peng¹  Ying Zhu²  Xueping Xie³  Jinfeng Liao³  Sirong Shi³  Taorang Tian³  Yunfeng Lin⁴ 

[1] Department of Oral and Maxillofacial Surgery, The Affiliated Stomatology Hospital of Southwest Medical University, 646000, Luzhou, China;Division of Physical Biology, CAS Key Laboratory of Interfacial Physics and Technology, Shanghai Synchrotron Radiation Facility, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, 201800, Shanghai, China;Zhangjiang Laboratory, Shanghai Advanced Research Institute, Chinese Academy of Sciences, 201210, Shanghai, China;State Key Laboratory of Oral Diseases, National Clinical Research Centre for Oral Diseases, West China Hospital of Stomatology, Sichuan University, 610041, Chengdu, China;State Key Laboratory of Oral Diseases, National Clinical Research Centre for Oral Diseases, West China Hospital of Stomatology, Sichuan University, 610041, Chengdu, China;College of Biomedical Engineering, Sichuan University, 610041, Chengdu, China;

关键词: Gold nanorods;    Systemic biocompatibility;    Macaca fascicularis;    Blood clearance;    Biodistribution;    Major organ analysis;   

DOI  :  10.1186/s12951-021-00941-1

来源: Springer

【 摘 要 】

BackgroundThe biomedical field has used gold nanorods (GNRs) for decades; however, clinical trials and translation is limited except gold nanoshells. The preparation of gold nanoshells is more complex than that of polyethylene glycol-modified GNRs (PEG-GNRs), and it is difficult to ensure uniform thickness. It is important to encourage and broaden the use of the star member (PEG-GNRs) of gold nanoparticles family for clinical translation. Existing studies on PEG-GNRs are limited with no relevant systematic progression in non-human primates. Herein, we assessed the systematic biocompatibility of PEG-GNRs in rats and clinically relevant Macaca fascicularis.ResultsIn this small animal study, we administrated multiple doses of PEG-GNRs to rats and observed good biocompatibility. In the non-human primate study, PEG-GNRs had a longer blood half-life and produced a negligible immune response. Histological analysis revealed no significant abnormality.ConclusionsPEG-GNRs were well-tolerated with good biocompatibility in both small animals and large non-human primates. The information gained from the comprehensive systemic toxicity assessment of PEG-GNRs in M. fascicularis will be helpful for translation to clinical trials.Graphical abstract

【 授权许可】

CC BY